乳腺癌动态增强磁共振成像与Her-2、Ki-67表达的相关性  

Correlation between DCE-MRI features and the expression of Her-2 and Ki-67 in breast cancer

作　　者：安丽华[1] 时克伟[1] 李静[1] 冯海霞[1] 赵小春[1] 王唯伟 孙新海[1] An Li-hua;Shi Ke-wei;Li Jing;Feng Hai-xia;Zhao Xiao-chun;Wang Wei-wei;Sun Xin-hai(Department of Radiology, Affiliated Hospital of Jining Medical University, Jining 272000, Shandong, Chin)

机构地区：[1]济宁医学院附属医院医学影像科,山东济宁272000

出　　处：《兰州大学学报（医学版）》2018年第3期51-55,共5页Journal of Lanzhou University（Medical Sciences）

基　　金：济宁市科技发展计划项目(济科字[2015]57号-128)

摘　　要：目的研究乳腺癌动态增强磁共振成像(DCE-MRI)表现与人表皮生长因子受体-2(Her-2)、Ki-67表达的相关性。方法对80例乳腺癌患者术前行DCE-MRI检查,分析其影像学表现,包括肿块大小、形态、边缘、时间信号强度曲线、强化形式、早期增强率等。术后标本行免疫组织化学染色测定肿瘤细胞Her-2、Ki-67表达情况。分析DCE-MRI表现与Her-2、Ki-67表达的相关性。结果乳腺癌肿块强化形式及早期增强率与Her-2存在相关性(P<0.05);肿块形态、强化形式及时间—信号强度曲线类型与Ki-67存在相关性(P<0.05)。结论乳腺癌DCE-MRI表现与Her-2、Ki-67表达存在一定的相关性,可以间接评估肿瘤预后并为临床治疗方案提供参考。Objective To study the correlation between features of dynamic contrast-enhanced magnetic resonance imaging（DCE-MRI） and the expression of human epidermal growth factor receptor 2, Her-2 and Ki-67 in breast cancer. Methods DCE-MRI was performed in 80 cases of breast cancer before operation and imaging features of breast cancer analyzed. The expression of Her-2 and Ki-67 in postoperative specimens was measured by immunohistochemistry. The correlation between DCE-MRI features and the expression of Her-2 and Ki-67 in breast cancer was analyzed using χ~2 test. Results The features of tumor morphology, enhancement pattern and the time-signal intensity curve（TIC）type were positively correlated with Ki-67（P〈0.05）;tumor enhancement pattern and early enhancement rate were positively correlated with Her-2（P〈0.05）.Conclusion There is some correlation between the DCE-MRI features and the expression of Her-2 and Ki-67 in breast cancer. DCE-MRI can provide a reference for indirect assessment of prognosis and clinical treatment planning.

关 键 词：乳腺癌 磁共振成像 人表皮生长因子受体-2 KI-67 

分 类 号：R737.9[医药卫生—肿瘤]