前列腺癌转移动物模型特性的比较学分析  

Advances in constructing metastatic animal models of prostate cancer

作　　者：饶玉良 孙祖越[1,2,3] RAO Yu-liang;SUN Zu-yue(Dept of Pharmacology and Toxicology, Shanghai Institute of Planned Parenthood Research,National Evaluatioo Center for the Toxicology of Fertility Regulatioo Drugs, Shanghai 200032, China;School of Medicine, Fudan University, Shanghai 200031, China;National Population and Family Planning Commission Key Lab of Contraceptivv Drugs ＆ Deices , Shanghai 200032, China)

机构地区：[1]上海市计划生育科学研究所药理毒理学研究室中国生育调节药物毒理检测中心,上海200032 [2]复旦大学药学院,上海200031 [3]国家人口和计划生育委员会计划生育药具重点实验室,上海200032

出　　处：《中国药理学通报》2018年第6期760-764,共5页Chinese Pharmacological Bulletin

基　　金：上海市"科技创新行动计划"实验动物研究领域科技支撑项目(No 17140900801);上海科技服务平台项目(No17DZ2293600)

摘　　要：前列腺癌是男性泌尿生殖系统常见肿瘤,肿瘤转移是前列腺癌常见的并发症和致死因素。研究前列腺癌转移具有重要的临床意义,合适的前列腺癌转移模型是研究前列腺癌发生、进展、转移及药物研究的重要工具。该文介绍了目前常见的人前列腺癌转移模型,并从转移模型的操作、评估、应用等方面比较各种模型的特点,有利于前列腺癌的模型研究和选择。Prostate cancer is a common neoplasm of the genitou-rinary system for male,and tumor metastasis of prostate cancer is a common complication and a lethal factor. Researching on prostate cancer metastasis is very important for clinical research and treatment. Proper models of prostate cancer metastasis are important tools for the study of occurrence,progression,metastasis,and drug research for prostate cancer. This article introduces the common model of human prostate cancer metastasis,including the points of operation,evaluation,application of metastatic models and comparing the characteristics of various models,to the benefit of researching and selecting models of prostate cancer.

关 键 词：前列腺癌 动物模型 肿瘤转移 转移模型 评价方法 人源组织异种移植PDX 

分 类 号：R-05[医药卫生] R363-332