慢肝养阴片防治抗结核药物所致肝损害的临床疗效  

Clinical effect of Mangan Yangyin tablets on the prevention and treatment of liver damage caused by anti-tuberculosis drugs

作　　者：房荣[1] 谢梅[1] FANG Rong;XIE Mei(Yan＇an People＇s Hospital,Yan＇an 715000,China)

机构地区：[1]延安市人民医院,陕西延安715000

出　　处：《临床医学研究与实践》2018年第15期108-109,共2页Clinical Research and Practice

摘　　要：目的探讨慢性养阴片对抗结核药物所致肝损害的防治效果。方法选入2014年1月至2017年6月我院收治的结核病患者164例,随机分为对照组和观察组,每组82例,两组均采用"2HRZE(S)/4HR"方案进行抗结核治疗,观察组加服慢肝养阴片,对照组不用保肝药物,待肝功能出现异常时加用凯西莱。评价两组的治疗效果及肝损害情况。结果经抗结核治疗6个月,观察组肝损害发生率为6.10%,明显低于对照组的21.95%(P<0.05);观察组成功完成抗结核化疗率明显高于对照组(P<0.05),且无明显不良反应。结论慢性养阴片可有效预防抗结核药物所致肝损害的发生几率,促进患者规律、有效地完成抗结核化疗过程。Objective To investigate the effect of Mangan Yangyin tablets on the prevention and treatment of liver damage caused by anti-tuberculosis drugs. Methods One hundred and sixty-four patients with tuberculosis in our hospital from January 2014 to June 2017 were randomly divided into control group and observation group, with 82 cases in each group.All the patients were treated with 2HRZE（S）/4HR for anti-tuberculosis treatment, and the observation group combined with Mangan Yangyin tablets, the control group without liver protecting drugs, when the abnormal liver function with tiopronin.The treatment effects and liver damage in the two groups were evaluated. Results After 6 months of treatment, the incidence of liver damage in the observation group was 6.10%, which was significantly lower than 21.95% in the control group （P〈0.05）. The successful completion rate of anti-tuberculosis chemotherapy in the observation group was significantly higher than that in the control group （P〈0.05）, and there was no obvious adverse reaction. Conclusion Mangan Yangyin tablets can effectively prevent the occurrence of liver damage caused by anti-tuberculosis drugs, and promote the patients to complete the process of anti-tuberculosis chemotherapy.

关 键 词：药物性肝损伤 结核病 慢肝养阴片 

分 类 号：R575[医药卫生—消化系统]