Association between IgG N-glycans and Nonalcoholic Fatty Liver Disease in Han Chinese  

作　　者：ZHAO Zhong Yao LIU Di CAO Wei Jie SUN Ming SONG Man Shu WANG Wei WANG You Xin 

机构地区：[1]Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University [2]School of Medical and Health Sciences, Edith Cowan University

出　　处：《Biomedical and Environmental Sciences》2018年第6期454-458,共5页生物医学与环境科学（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China[81673247];the National Natural Sciences Foundation of China(NSFC)-Australian National Health and Medical Research Council(NHMRC) Joint Research Project[NSFC 81561128020-NHMRC APP1112767]

摘　　要：Nonalcoholic fatty liver disease（NAFLD） is a major public health issue worldwide. Immunoglobulin G（IgG） N-glycans are associated with risk factors for NAFLD, such as obesity and diabetes. A cross-sectional study involving 500 Han Chinese adults recruited from a community in Beijing was carried out to explore the association between IgG N-glycans and NAFLD. IgG N-glycosylation was significantly associated with NAFLD, with the disease showing a negative correlation with galactosylation（GP14, GP14n, and G2n）, positive correlation with fucosylation（FBG2n/G2n）, and positive correlation with bisecting N-acetylglucosamine（Glc NAc） [FBG2n/FG2n and FBG2n/（FG2n＋FBG2n）], after controlling age, gender, and prevalence of obesity, type 2 diabetes mellitus, hypertension, and hyperlipidemia. In other words, the present study showed a possible association between NAFLD and the loss of galactose and elevations of fucose and bisecting GlcNAc. Aberrant IgG glycosylation might therefore be a potential biomarker for the primary or secondary prevention of NAFLD.Nonalcoholic fatty liver disease（NAFLD） is a major public health issue worldwide. Immunoglobulin G（IgG） N-glycans are associated with risk factors for NAFLD, such as obesity and diabetes. A cross-sectional study involving 500 Han Chinese adults recruited from a community in Beijing was carried out to explore the association between IgG N-glycans and NAFLD. IgG N-glycosylation was significantly associated with NAFLD, with the disease showing a negative correlation with galactosylation（GP14, GP14n, and G2n）, positive correlation with fucosylation（FBG2n/G2n）, and positive correlation with bisecting N-acetylglucosamine（Glc NAc） [FBG2n/FG2n and FBG2n/（FG2n＋FBG2n）], after controlling age, gender, and prevalence of obesity, type 2 diabetes mellitus, hypertension, and hyperlipidemia. In other words, the present study showed a possible association between NAFLD and the loss of galactose and elevations of fucose and bisecting GlcNAc. Aberrant IgG glycosylation might therefore be a potential biomarker for the primary or secondary prevention of NAFLD.

关 键 词：NAFLD IGG Association between IgG N-glycans and Nonalcoholic Fatty Liver Disease in Han Chinese FBG 

分 类 号：R575.5[医药卫生—消化系统]