贵州省2016年中药材饮片中黄曲霉毒素污染调查  

Pollution Investigation of Aflatoxins in Traditional Chinese Medicines from Guizhou Province in 2016

作　　者：杨畅 刘帆 李莉娜 刘春花 王爱民 YANG Chang;LIU Fan;LI Lina;LIU Chunhua;WANG Aimin(School of Pharmacy , Guizhou Medical University, Guiyang 550004;Guizhou Provincial Key Lab. of Pharmaceutics. Guiyang 550004;Engineering Technology Research Center for Miao Pharmaceutics, Guiyang 550004;Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, Ministry of Education. Guiyang 550004)

机构地区：[1]贵州医科大学药学院,贵州贵阳550004 [2]贵州省药物制剂重点实验室,贵州贵阳550004 [3]国家苗药工程技术研究中心,贵州贵阳550004 [4]民族药与中药开发应用教育部工程研究中心,贵州贵阳550004

出　　处：《中国医药工业杂志》2018年第7期956-961,共6页Chinese Journal of Pharmaceuticals

摘　　要：以贵州省制药企业常用的16种中药材为研究对象,收集了2016年贵州省制药、饮片生产企业的130个样品,采用免疫亲和柱色谱高效液相色谱法测定其中所含的黄曲霉毒素B1、B2、G1和G2,了解贵州省常用中药材中黄曲霉毒素的污染状况,为贵州省中药材的质量控制提供数据参考。其中,陈皮、大枣等果皮果实类中药材的黄曲霉毒素污染水平总体较低,而种子种仁类中药材(如柏子仁、槟榔等)和动物类药材(如蜈蚣、僵蚕等)存在较高程度的污染,应予以重视。Taking 16 kinds of Chinese herbal medicine commonly used by pharmaceutical enterprises in Guizhou province as the research object to investigate the pollution of aflatoxins in traditional Chinese medicincse （TMC）. 130 Batches of different kinds of TMC from the pharmaceutical enterprises in Guizhou province were collected in 2016. The contents of aflatoxin B1, B2, G1 and G2 were determined by HPLC with immune affinity column chromatography, which was recorded in the Chinese pharmacopoeia 2015 edition, in order to reveal the pollution status of aflatoxins in the traditional Chinese medicinal herbs of Guizhou and provide data for the quality control of these medicinal herbs. Among them, the aflatoxin pollution levels of tangerine peel, jujube and other fruit-type Chinese herbal medicines were generally low, while the seed species （such as biota seed, betel nut, etc.） and animal medicines （such as centipede, Bombyx batryticatus, etc.） had higher degrees of pollution, which should be paid attention to.

关 键 词：中药材 中药饮片 黄曲霉毒素 含量测定 污染评价 

分 类 号：R93[医药卫生—生药学]