人乳头状瘤病毒分型及肿瘤标志物联合检测在宫颈癌前病变及宫颈癌中的诊断应用分析  

Diagnostic application of HPV typing and tumor markers in cervical precancerous lesions and cervical cancer

作　　者：柯然利[1] 孙慧儿 喻燕雯[1] KE Ran - li;SUN Hui - er;YU Yan - wen(Department of Gynecology, the First People＇s Hospital of Yuhang District, Hangzhou, Zhejiang 311100, China)

机构地区：[1]杭州市余杭区第一人民医院妇科,浙江杭州311100

出　　处：《中国卫生检验杂志》2018年第12期1476-1478,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨HPV分型及肿瘤标志物联合检测在宫颈癌前病变及宫颈癌中的诊断应用分析。方法选取2015年6月-2017年8月本院40例宫颈癌患者纳入宫颈癌组,40例宫颈癌前病变患者纳入宫颈癌前病变组,40例体检健康女性纳入健康对照组。比较3组对象HPV亚型阳性结果以及肿瘤标志物Scc、CA125水平、Ki67阳性表达率。结果宫颈癌前病变组及宫颈癌组HPV16、HPV18阳性例数显著高于健康对照组,宫颈癌组HPV16、HPV18阳性例数显著高于宫颈癌前病变组,上述差异均有统计学意义(P<0.05),而3组受试者HPV31、HPV58阳性例数差异无统计学意义(P>0.05)。宫颈癌前病变组及宫颈癌组Scc、CA125、Ki67水平显著高于健康对照组,宫颈癌组Scc、CA125、Ki67水平显著高于宫颈癌前病变组;3组受试者Scc、CA125、Ki67联合检测阳性率较各单项检测阳性率显著提高,上述差异均有统计学意义(P<0.05)。结论 HPV分型、Scc、CA125、Ki67联合检测有助于宫颈癌的早期诊断,更明确的检测结果有待于进一步研究。Objective To investigate the diagnostic application of HPV typing and tumor markers in cervical precancerous lesions and cervical cancer. Methods In our hospital from June 2015 to August 2017,40 cases of cervical cancer patients were selected as the cervical cancer group; 40 cases of cervical precancerous lesions patients were selected as the cervical precancerous lesion group; and 40 healthy women were selected as the control group. The positive results of HPV subtype,the levels of tumor markers（Scc,CA125） and the positive expression rate of Ki67 were compared among the three groups. Results The number of HPV16 and HPV18 positive cases in cervical precancerous lesion group and cervical cancer group were significantly higher than that in healthy control group; the number of HPV16 and HPV18 positive cases in cervical cancer group were significantly higher than that in cervical precancerous lesion group,with the above differences statistically significant（P〈0. 05）;there was no statistical significance on the differences among the three groups in the positive numbers of HPV31 and HPV58（P〈0. 05）. The levels of Scc,CA125 and Ki67 in cervical precancerous lesion group and cervical cancer group were significantly higher than those in healthy control group; the levels of Scc,CA125 and Ki67 in the cervical cancer group were significantly higher than those in the cervical precancerous lesion group. The positive rate of combined detection of Scc,CA125 and Ki67 in three groups was significantly higher than that of each individual test,with the above differences statistically significant（P〈0. 05）. Conclusion HPV type detection,combined detection of Scc,CA125 and Ki67 are helpful for the early diagnosis of cervical cancer,and more clear detection results need to be further studied.

关 键 词：HPV分型 肿瘤标志物 联合检测 宫颈癌前病变 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]