MAOA与肿瘤关系的研究进展  

Progress in the relationship between MAOA and tumor

作　　者：黄炳御 唐旭东 HUANG Bing-Yu;TANG Xu-Dong(Institute of Biochemistry and Molecular Biology, Collaborative Innovation Center for Antitumor Active Substance Research and Development, Guangdong Medical University, Zhanjiang 524023, Chin)

机构地区：[1]广东医科大学生物化学与分子生物学研究所广东医科大学抗肿瘤活性物质研发协同创新中心,湛江524023

出　　处：《生命科学》2018年第5期545-550,共6页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(81372511);广东省自然科学基金项目(2017A030313539);广东省产业技术开发研究与开发专项资金项目(2013B031100002);广东省"扬帆计划"培养高层次人才项目(201635011)

摘　　要：单胺氧化酶A(monoamine oxidase A,MAOA)是一种线粒体结合酶,已证实其缺陷与负面情绪密切相关。近几年发现MAOA在部分肿瘤的发生、发展和预后中起到重要作用。现对MAOA在前列腺癌、肝癌、胆管癌、淋巴瘤、乳腺癌、胰腺癌中的表达以及作用的研究进展进行综述,并且展望未来MAOA在肿瘤研究中的方向及其临床应用前景。Monoamine oxidase A, a mitochondrial-binding enzyme, has a close association with negative emotions. In recent years, MAOA has been found to play an important role in the occurrence, development, and prognosis of some tumors. This review summarized MAOA expression in prostate cancer, hepatocellular carcinoma, cholangiocarcinoma, lymphoma, breast cancer, and pancreatic ductal adenocarcinoma as well as the research progress on the role of MAOA in these tumors, and also gived fresh perspectives on further investigation and clinical application of MAOA.

关 键 词：单胺氧化酶A 肿瘤 机制 

分 类 号：Q71[生物学—分子生物学] R73[医药卫生—肿瘤]