抽动障碍儿童Th淋巴细胞及其亚群的变化  

Changes in T helper lymphocytes and their subsets in children with tic disorders

作　　者：侯晓君 林珊 林祥泉 黄林娟 黄巧燕 HOU Xiao-Jun;LIN Shan;LIN Xiang-Quan;HUANG Lin-Juan;HUANG Qiao-Yan(Department of Neurology, Fuzhou Children ＇s Hospital of Fujian Province, Fuzhou 350005, Chin)

机构地区：[1]福建省福州儿童医院神经内科,福建福州350005

出　　处：《中国当代儿科杂志》2018年第7期519-523,共5页Chinese Journal of Contemporary Pediatrics

基　　金：福州市科技计划项目社会发展项目(2016-S-128)

摘　　要：目的探讨抽动障碍(TD)儿童T辅助(Th)淋巴细胞及其亚群表达变化的临床意义。方法采用流式细胞技术检测TD组和对照组(健康儿童)外周血中Th淋巴细胞及其亚群的表达水平。结果与对照组比较,TD组Th淋巴细胞的百分比明显降低,差异有统计学意义(P<0.001);Th淋巴细胞的异常率为68.7%,比对照组(18.8%)增高(P<0.001);而且Th淋巴细胞百分比和耶鲁综合抽动严重程度评分呈负相关(r=-0.3945,P<0.001)。在Th淋巴细胞亚群中,TD组Th1淋巴细胞百分比明显高于对照组,而Th2淋巴细胞百分比明显低于对照组,差异均有统计学意义(P<0.001)。结论 Th淋巴细胞及其亚群的平衡失调导致的细胞免疫功能异常可能与儿童TD的发生相关,且Th淋巴细胞水平可作为评估TD严重程度的指标。Objective To explore the changes in T helper lymphocytes and their subsets in children with tic disorders（TD） and their clinical significance. Methods Flow cytometry was used to measure the percentages of T helper lymphocytes and their subsets in the peripheral blood of children with TD and healthy children（controls）. Results The percentage of T helper lymphocytes was significantly lower in the TD group than in the control group（P〈0.001）. The abnormal rate of T helper lymphocytes in the TD group was significantly higher than that in the control group（68.7% vs 18.8%; P〈0.001）. The percentage of T helper lymphocytes was negatively correlated with Yale Global Tic Severity Scale score（r=-0.3945, P〈0.001）. As for the subsets of T helper lymphocytes, the TD group had a significantly higher percentage of Th1 cells and a significantly lower percentage of Th2 cells compared with the control group（P〈0.001）. Conclusions The abnormality of T helper lymphocytes and the imbalance of their subsets may be associated with the pathogenesis of TD in children. The percentage of T helper lymphocytes can be used as an indicator for assessing the severity of TD.

关 键 词：抽动障碍 T辅助淋巴细胞 儿童 

分 类 号：R749.94[医药卫生—神经病学与精神病学]