白细胞介素-6在三阴性乳腺癌患者血清中的表达  

Expression and clinical significance of serum interleukin -6 in triple negative breast cancer

作　　者：韩国晖[1] 白向东[1] 张渤[1] 刘玉江[1] Han Guohui;Bai Xiangdong;Zhang Bo;Liu Yufiang(Department of Breast Surgery, Shanxi Provincial Cancer Hospital, Taiyuan 030013, China)

机构地区：[1]山西省肿瘤医院乳腺外科,太原030013

出　　处：《中华实验外科杂志》2018年第7期1318-1320,共3页Chinese Journal of Experimental Surgery

摘　　要：目的探讨白细胞介素-6（IL-6）在三阴性乳腺癌（TNBC）患者血清中表达及临床意义。方法选择2014年7月至2016年10月在山西省肿瘤医院乳腺外科住院治疗乳腺肿瘤患者156例，其中TNBC52例，非TNBC79例，乳腺良性肿瘤25例，采用酶联免疫吸附试验（ELISA）检测乳腺肿瘤患者血清中IL-6水平，分析IL-6与TNBC临床病理特征的关系。结果IL-6在乳腺良性肿瘤、非TNBC、TNBC患者血清中水平分别为（13．3±4．7）、（79．9±19．5）、（114．2±21．9）pg／ml，差异有统计学意义（P=0．000）；TNBC患者血清中IL-6水平高于非TNBC患者，差异有统计学意义（P=0．000）；肿瘤〉2cm和淋巴结转移的TNBC患者血清中IL-6水平明显均高于肿瘤≤2cm和淋巴结未转移的患者，差异有统计学意义（P=0．000、0．020）。结论IL-6在TNBC患者血清中高表达，可能可作为TNBC的诊断标志物。Objective To evaluate the expression and clinical significance of interleukin -6 （ IL - 6） in triple negative breast cancer （TNBC）. Methods One hundred and fifty - six cases including 52 cases of TNBC, 79 cases of non - triple negative breast and 25 cases of benign breast disease. Serum IL - 6 level was detected by using enzyme linked immunosorbent assay （ELISA）. The difference of IL - 6 level in the three groups was analyzed. The correlation between serum IL -6 level and clinicopathological parameters of TNBC including age, menopause status, tumor size, lymph node metastasis and TNM stage was examined. Results The serum IL - 6 level in groups of benign breast disease, non - triple negative breast cancer and TNBC was （ 13.3 ± 4. 7）, （79.9 ± 19. 5 ）, （ ll4.2 ± 21.9） pg/ml respectively. The difference between the three groups differed significantly （ P = 0. 000）. The level of serum IL - 6 in TNBC with tumor size 〉 2 cm and lymph node metastasis was higher than that with tumor size≤ 2 cm and no lymph node metastasis, and the difference differed significantly （ P = 0. 000, 0.020 ）. Conclusion IL - 6 level was highly in the serum of TNBC and it maybe a diagnosis marker and therapeutic target.

关 键 词：白细胞介素-6 三阴性乳腺癌 血清 

分 类 号：R737.9[医药卫生—肿瘤]