TM4SF1在脑胶质瘤组织的表达及其临床意义  

The expression and clinical significance of transmembrane - 4 - L - six - family - 1 in human glioma

作　　者：王鹏[1] 赵家慧 包文娟[3] 丛璐璐[1] 胡红超[1] 赵宗茂[1,4] Wang Peng;Zhao Jiahui;Bao Wenjuan;Cong Lulu;Hu Hongchao;Zhao Zongmao(Department of Netrrosurgery , the Second Hospital of Hebei Medical University, Shijiazhuang 050003, China （ Wang P, Cong LL, Hu HC, Zhao ZM;Clinical Class 3, Grade 2014, Department of Clinical Medicine, Hebei University, Baoding 071030, China （ Zhao JH;Department of Anesthesiology, Children＇s Hospital of Hebei Province, Shijiazhuang 050017, China （Bao WJ;Neuroscience Research Center, Hebei Medical University, Shijiazhuang Hebei 050017, China （Zhao ZM） Wang Peng and Zhao Jiahui are the first authors who contributed equally to the articl)

机构地区：[1]河北医科大学第二医院神经外科,石家庄050003 [2]河北大学医学院2014级临床三班,保定071030 [3]河北省儿童医院麻醉科,石家庄050017 [4]河北医科大学神经科学研究中心,石家庄050017

出　　处：《中华实验外科杂志》2018年第7期1338-1341,共4页Chinese Journal of Experimental Surgery

基　　金：河北省医学科学研究重点课题（20170077）;河北省医学实用技术跟踪项目（G201717）;河北省政府资助临床医学优秀人才培养和基础课题研究项目

摘　　要：目的探讨TM4SF1在脑胶质瘤组织的表达及临床意义。方法应用免疫组织化学方法测定98例人脑胶质瘤组织及9例正常脑组织中TM4SF1及CD34的表达，并分析TM4SF1与临床病理级别、生存期的相关性。结果TM4SF1在正常脑组织中阴性表达，在胶质瘤组织中的阳性表达率为82．65％，差异有统计学意义（P=0．000）。低级别和高级别胶质瘤组织阳性表达率分别为69．23％和91．53％，差异有统计学意义（P=0．004）。CD34标记的微血管密度（MVD）在胶质瘤组织和正常脑组织中的表达均值分别为36．354±7．984和3．625±0．415，差异有统计学意义（P=0．000）。MYD在TM4SF1表达阳性和阴性的胶质瘤组织中表达均值分别为：37．881±7．391和29．078±6．730，差异有统计学意义（P=0．000）。单因素及多因素分析显示TM4SF1高表达是脑胶质瘤患者预后不良的独立危险因素（P=0．016）。结论TM4SF1的表达水平与胶质瘤的病理级别、患者的预后明显相关，并参与胶质瘤的血管新生。Objective To investigate the expression and clinical significance of transmembrane - 4 - L - six - family - 1 （ TM4SF1 ） in human glioma. Methods The expression of TM4SF1 protion and CD34 in 98 cases of glioma tissues and 9 cases of normal brain tissues was examined by immunohistochemistry. The correlation of TM4SF1 with clinicopathological parmeters and survival of patients was analyzed statistically. Results TM4SF1 was negatively expressed in normal brain tissues （ P = 0. 000 ）. The total positive expression rate of TM4SF1 in tumor group was 82.65%. There was significant difference in TM4SFI expression between normal brain tissue and glioma tissue （P = 0. 000）, as well as between high - grade （91.53%） and low - grade （69.23%） tumor tissue （ P = 0.004）. The CD34 monoclonal antibody - labled microvessel density （ MVD ） in normal brain tissue group and tumor tissue group was 3. 625 ＋0. 415 and 36. 354 ＋ 7. 984. The value had significant difference （P = 0. 000）. The expression average of MVD respectively were 29. 078 ＋ 6. 730 and 37. 881 ＋ 7. 391 in negative and positive expression of TM4SF1 in glioma tissues, the data had significant difference （P = 0. 000）. Following univariate regression analysis and multivariate Cox regression analysis revealed that the expression of TM4SF1 was independent prognostic factors influencing survival（P =0. 016）. Conclusion TM4SF1 was related to patholog- ical grade and prognosis of glioma, and may take part in angiogenesis of glioma.

关 键 词：胶质瘤 预后 TM4SF1 微血管密度 

分 类 号：R739.41[医药卫生—肿瘤]