CPEB4在肿瘤中的研究进展  

The research progress of CPEB4 in tumor

作　　者：陈福海 郑安元 王永平[1] 戴梦源[1] 陶泽璋[1] 

机构地区：[1]武汉大学人民医院耳鼻咽喉头颈外科,武汉430060

出　　处：《临床耳鼻咽喉头颈外科杂志》2018年第13期1038-1042,共5页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：国家自然科学基金项目(No:81372880)

摘　　要：二十多年前,Hake.等在卵母细胞成熟的过程中首次发现胞质多聚腺苷酸化元件结合蛋白（cytoplasmic polyadenylation element binding proteins,CPEBs）,指出其mRNA及蛋白在卵母细胞中表达异常丰富;CPEB4在一些已确定的mRNA的翻译过程中起着重要的调控作用,在CPEB蛋白发生磷酸化的同时会诱导聚腺苷酸化,而细胞质内聚腺苷酸化导致的Poly（A）尾延长可以激活一些母系mRNA的翻译[1]。Cytoplasmic polyadenylation element binding protein 4（Cytoplasmic polyadenylation element binding protein 4,CPEB4）,a newly discovered member of the cytoplasmic polyadenylation element binding proteins,is a kind of RNA-binding proteins with mediator of mRNA cytoplasmic polyadenylation and translation.CPEB4 plays an important role in the proliferation,migration,invasion and interstitial transformation of many tumors.In recent years,studies have shown that CPEB4 has abnormal expression in a variety of human tumors,and the abnormal expression of cancer patients has a significant correlation with the prognosis.Based on the current research progress,the purpose of this article is to further understand the relationship between CPEB4 and malignant tumor and its molecular mechanism of regulating tumorigenesis and to provide a new direction and means for the molecular diagnosis and targeted therapy of malignant tumor.

关 键 词：多聚腺苷酸化元件结合蛋白4 肿瘤 异常表达 靶向治疗 

分 类 号：R739.6[医药卫生—肿瘤]