CAFs的活化机制及其在肿瘤发生发展中的作用  

The Activation Mechanism of CAFs and Its Role in the Development of Tumor

作　　者：陈曦 杨力芳[2] 李丹[1] CHEN Xi;YANG Li-fang;LI Dan(College of Biology, Hunan University, Changsha 410082, Hunan, China;Ontology Institute, Central South University, Changsha 410008, Hunan, China)

机构地区：[1]湖南大学生物学院,中国湖南长沙410082 [2]中南大学肿瘤研究所,中国湖南长沙410008

出　　处：《生命科学研究》2018年第3期235-242,共8页Life Science Research

摘　　要：肿瘤的发生发展不仅与肿瘤细胞本身有关,还与肿瘤微环境(tumor microenvironment)有密切关系。肿瘤相关成纤维细胞(cancer associated fibroblasts,CAFs)是肿瘤微环境中的主要成分之一,它能促进肿瘤的生长、侵袭转移以及血管生成。研究认为CAFs主要来源于肿瘤周围间质组织中的成纤维细胞(normal fibroblasts,NFs),此外也可来源于肿瘤干细胞和肿瘤间质中的其他细胞。NFs可经过肿瘤微环境中一些可溶性的细胞因子诱导,发生一系列的表型改变及功能基因的差异表达,从而活化为CAFs。癌蛋白以及mi RNA也均可诱导NFs向CAFs转化,从而调控肿瘤的发生发展。因此,深入研究CAFs的活化途径和机制以及它在肿瘤发生发展中的作用是肿瘤微环境研究中的重要问题,可对今后肿瘤的治疗产生一定的推进作用。The development of tumor is not only related to tumor cell itself, but also has a close relationship with tumor microenvironment. The cancer associated fibroblasts（CAFs） can promote tumor growth, invasion and metastasis, and angiogenesis, which are supposed to be the main components in the tumor microenvironment.Researches suggest that CAFs mainly come from the normal fibroblasts（NFs） in the tumor stromal tissues, and can also be derived from tumor stem cells and other cells of tumor stroma. NFs can be activated into CAFs by some soluble signaling molecules in tumor microenvironment, thus leading to phenotype changes and functional genes being differentially expressed. Oncoproteins and mi RNAs can also activate NFs into CAFs,thereby regulating the development of tumor. Therefore, it＇s important in the study of the tumor microenvironment to explore the mechanism and pathway of activation in CAFs and their roles in tumor development.These researches also have a positive effect on the treatment of tumors in the future.

关 键 词：肿瘤微环境 肿瘤相关成纤维细胞(CAFs) CAFs的活化 肿瘤发生发展 肿瘤治疗 

分 类 号：Q28[生物学—细胞生物学] R730.2[医药卫生—肿瘤]