外周血PG和G17水平联合Hp-IgG抗体检测对老年胃癌及癌前病变的诊断价值  

Diagnostic value of PG,G17 levels in peripheral blood combined with detection of Hp-IgG antibody for elderly gastric cancer and precancerous lesions

作　　者：嵇贝纳 冯珍 程中华 王绍英 JI Bei-na;FENG Zhen;CHENG Zhong-hua;WANG Shao-ying(Department of Gastroenterology, Xuhui Hospital of Zhongshan University, Shanghai 200012, China)

机构地区：[1]上海市中山医院徐汇医院消化内科,上海200012

出　　处：《中国肿瘤临床与康复》2018年第6期648-650,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨外周血胃蛋白酶原(PG)和促胃液素17(G17)水平联合Hp-IgG抗体检测对老年胃癌及癌前病变的诊断价值。方法选取2016年2月至2018年2月间上海市中山医院徐汇医院收治的80例老年胃部不适患者,均行胃镜检查并取活组织病理检查。统计不同血清胃分泌功能检测结果患者的胃癌发生情况,不同胃镜检查病理结果患者的PGⅠ、PGⅡ、PGR和G17水平,不同萎缩性胃炎萎缩程度、部位患者的PGⅠ、PGⅡ、PGR和G17水平。结果 PG和Hp均阴性、PG阴性和Hp阳性、PG和Hp均阳性及PG阳性和Hp阴性患者的胃癌发生率分别为2.5%(1/40)、3.3%(1/30)、16.7%(1/6)及25.0%(1/4),逐渐提升(P<0.05)。胃癌患者外周血PGⅠ和PGR均低于非萎缩性胃炎和萎缩性胃炎患者,差异均有统计学意义(均P<0.05)。重度萎缩性胃炎患者外周血PGⅡ水平均高于轻度和中度萎缩性胃炎患者,PGR均低于轻度和中度萎缩性胃炎患者,差异均有统计学意义(均P<0.05)。胃窦、胃体和全胃萎缩性胃炎患者的外周血G17水平逐渐提升,差异均有统计学意义(均P<0.05)。结论外周血PG和G17水平联合Hp-IgG抗体对老年胃癌及癌前病变的诊断价值高。Objective To analyze the value of pepsinogen（ PG）,gastrin 17（ G17） and Hp-IgG antibody in the diagnosis of gastric cancer and precancerous lesions in the elderly. Methods A total of 80 elderly patients with stomach discomfort treated at Xuhui Hospital of Zhongshan University from February2016 to February 2018 were randomly selected. All patients underwent gastroscopy and biopsy for gastric secretory function. The incidence of gastric cancer was counted in patients with different serum test results.The PG Ⅰ and PG Ⅱ,PGR and G17 levels in peripheral blood were statistically analyzed in patients with different gastroscopy and pathology results. The PG Ⅰ and PG Ⅱ,PGR and G17 levels in peripheral blood were also analyzed in patients with atrophic gastritis of different degrees at different sites. Results The incidence rate of gastric cancer was 2. 5%（ 1/40）,3. 3%（ 1/30）,16. 7%（ 1/6） and 25. 0%（ 1/4） in patients with both PG and Hp negative,PG negative and Hp positive,both PG and Hp positive,PG positive and Hp negative,which was gradually increased（ P〈 0. 05）. The PG Ⅰ and PGR levels in peripheral blood were significantly lower in patients with gastric cancer than patients with or without atrophic gastritis（ all P〈 0. 05）. The PG Ⅱ level in peripheral blood was significantly higher in patients with severe atrophic gastritis than patients with mild and moderate atrophic gastritis and the PGR level was significantly lower in patients with severe atrophic gastritis than patients with mild and moderate atrophic gastritis（ all P〈 0. 05）.The G17 level in peripheral blood gradually increased in gastric antrum,gastric body and total gastric atrophic gastritis patients（ all P〈 0. 05）. Conclusion PG,G17 and Hp-IgG antibody is significant in the diagnosis of gastric cancer and precancerous lesions in the elderly.

关 键 词：外周血 PG G17 Hp-IgG抗体 老年胃肿瘤 癌前病变 

分 类 号：R735.2[医药卫生—肿瘤]