茉莉醛合成工艺研究  

Study on Synthesis of Jasminaldehyde

作　　者：陈敏琼 刘继鸿 蔡泽威 李梓童 张红 CHEN Min - qiong;LIU Ji - hong;CAI Ze - wei;LI Zhi - tong;ZHANG Hong(School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan 528458, Guangdong, China;Guangdong Cosmetics Engineering ＆ Technology Research Center, Guangzhou 510006, Guangdong, China)

机构地区：[1]广东药科大学医药化工学院,广东中山528458 [2]广东省化妆品工程技术研究中心,广东广州510006

出　　处：《香料香精化妆品》2018年第3期17-23,共7页Flavour Fragrance Cosmetics

摘　　要：主要探讨采用相转移催化法由苯甲醛和正庚醛经羟醛缩合合成茉莉醛的合成工艺。通过单因素试验法和正交试验法确定了合成茉莉醛的最佳工艺条件,当以4.567 g(0.04 mol)正庚醛为基准,苯甲醛与正庚醛的物质的量比为1.2:1,水25 mL,乙醇10 mL,氢氧化钾1.000 g(0.02 mol),PEG-400的用量为正庚醛的3%,60℃下反应4 h,茉莉醛粗产率达到84.3%,其结构经核磁共振氢谱和碳谱验证。Jasminaldehyde is a very valuable synthetic aroma chemical. Its synthetic process by aldol condensation of benzaldehyde and n-heptylaldehyde under phase transfer catalysis was mainly discussed in this paper. The optimal reaction conditions determined by both the single factor experiment and the orthogonal experiment were as follows： when 4.567 g（0.04 mol） heptylaldehyde was used, the reactant molar ratio of benzaldehyde to heptylaldehyde was 1.2 to 1, the amount of water was 25 mL, ethanol was 10 mL, KOH was 1.000 g（0.02 mol）, PEG-400 was 3% mole ratio of n-heptylaldehyde, reaction temperature was 60 ℃, reaction time was 4 hours, the yield of jasminaldehyde reached as high as 84.3%.

关 键 词：茉莉醛 正庚醛 相转移催化法 正交试验法 

分 类 号：TQ655[化学工程—精细化工]