HPV亚型与宫颈上皮内瘤变Ⅰ转归的关系  

Relationship of cervical HPV infection and outcomes of cervical intraepithelial neoplasia Ⅰ

作　　者：苏莉[1] 于澎静 夏林[1] SU Li;YU Pengjing;XIA Lin(Derpartment of Gynecology and Obstetrics, People＇s Hospital of Yangzhong, Yangzhong 212200, CHINA)

机构地区：[1]扬中市人民医院妇产科,江苏212200

出　　处：《江苏医药》2018年第6期668-670,共3页Jiangsu Medical Journal

基　　金：镇江市社会发展指导性项目(FZ2015058)

摘　　要：目的探讨HPV亚型与宫颈上皮内瘤变Ⅰ(CINⅠ)患者转归的关系。方法病理学确诊为CINⅠ患者886例,对其进行HPV-DNA分型测定。于确诊后4、8个月及1、2、3年随访CINⅠ转归情况。结果 886例中,自然好转或持续不变806例(≤CINⅠ),病理升级为CINⅡ/Ⅲ甚至宫颈浸润癌80例(≥CINⅡ)。HPV阳性481例:HPV16阳性59例,3年病理升级10例(16.95%);HPV52阳性53例,3年病理升级8例(15.09%);HPV53阳性62例,3年病理升级12例(19.35%);HPV68阳性25例,3年病理升级4例(16.00%)。HPV16、HPV52、HPV53和HPV68阳性患者3年累计病理升级率高于HPV阴性患者(P<0.05)。结论 HPV53、HPV16、HPV68和HPV52阳性的CINⅠ患者,病理升级风险较高。Objective To investigate the relationship of human papillomavirus（HPV）genotype and pathological upgrades of the patients with cervical intraepithelial neoplasia Ⅰ（CIN Ⅰ）.Methods The HPV-DNA typing was performed in 886 patients with CIN Ⅰ and the outcomes of the CIN Ⅰwere followed up in the 4^th and 8^th month and 1^st,2^nd and 3^rd year,respectively.Results Of 886 cases,806 cases were spontaneously improved or unchanged（≤CIN Ⅰ）,80 cases were upgraded to CIN Ⅱ-Ⅲ or invasive cervical cancer（≥CIN Ⅱ）.Of 481 cases with HPV positive,59 cases were HPV16 positive with pathologically 3-year upgrading rate of 16.95%（10/59）,53 cases were HPV52 positive with pathologically 3-year upgrading rate of 15.09%（8/53）,62 cases were HPV53 positive with pathologically 3-year upgrading rate of 19.35%（12/62）,and 25 cases were HPV68 positive with pathologically 3-year upgrading rate of 16.00%（4/25）.The pathologically 3-year upgrading cumulative rate of HPV positives was significantly higher than that of HPV negatives（P〈0.05）.Conclusions The CIN Ⅰ patients with HPV53,HPV16,HPV68 and HPV52 positive have a higher risk for histopathological upgrading.

关 键 词：宫颈上皮内瘤变 人类乳头状病毒 

分 类 号：R737[医药卫生—肿瘤]