幽门螺杆菌对于溃疡性结肠炎发生发展的临床意义  

Clinical significance of Helicobacter pylori in the grouth of ulcerative colitis

作　　者：葛永芳 管鑫 姜相君[1] Yong-Fang Ge;Xin Guan;Xiang-Jun Jiang(Department of Gastroenterology （Division Ⅱ）, Qingdao Municipal Hospital, Qingdao University Medical College, Qingdao 266000, Shandong Province, Chin)

机构地区：[1]青岛大学医学院附属青岛市市立医院消化内二科,山东省青岛市266000

出　　处：《世界华人消化杂志》2018年第17期1071-1076,共6页World Chinese Journal of Digestology

摘　　要：目的研究溃疡性结肠炎(ulcerative colitis,UC)患者感染幽门螺杆菌(Helicobacter pylori,H.pylori)的情况及两者关系.方法选取146例经肠镜及病理学检查确诊的UC患者为U C组;另选取150例经肠镜检查未见明显病变的健康体检者为对照组.回顾性分析两组经快速尿素酶试验和组织病理活检联合检测方法检测的H.pylori的感染情况.结果 UC组患者146例,27例阳性,H.pylori感染的阳性率为18.49%,对照组150例体检者,64例阳性,H.pylori感染的阳性率42.67%,UC组明显低于对照组,差异有统计学意义(P<0.05).按病变范围:直肠组27例,7例阳性,H.pylori阳性率为21.88%,左半结肠组48例,9例阳性,H.pylori阳性率为18.75%,广泛结肠组66例,11例阳性,H.pylori阳性率为16.67%.三组间比较,差异无统计学意义(P>0.05).活动期UC患者117例(80.14%),缓解期UC患者29例.缓解期H.pylori感染率阳性率最高(37.93%),重度活动期感染率最低(6.25%),差异较为明显(P<0.05).结论 H.pylori感染可能对UC的发生发展起预防保护作用,随疾病严重程度增加,H.pylori阳性率降低.此外加强UC患者的随访依从性也将非常重要.AIM To investigate the relationship between Helicobacter pylori（H. pylori） infection and ulcerative colitis（UC）.METHODS One hundred and forty-six patients with UC diagnosed by colonoscopy and pathological examination were selected as a UC group. In addition, 150 volunteers who had no obvious colonic lesions as detected by electronic colonoscopy were collected as a control group. Rapid urease test and histopathological biopsy were used to detect H. pylori infection.RESULTS In UC Group, 146 cases, 27 positive, H. pylori infection positive rate of 18.49%, control group of 150 cases, 64 positive, H. pylori infection positive rate 42.67%, UC group is significantly lower than the control group, the difference is statistically significant（P〈0.05）. According to lesion Range： Rectal Group 27 cases, 7 positive, H. pylori positive rate is 21.88%, left half colon group 48 cases, 9 cases positive, H. pylori positive rate is 18.75%, extensive colon group 66 cases, 11 cases positive, H. pylori positive rate is 16.67%. There was no statistically significant difference among the three groups（P〉0.05）. Active period of UC patients in 117 cases（80.14%）, remission period of UC patients in 29 cases. The positive rate of H. pylori infection was the highest in remission period（37.93%）, the lowest rate of severe activity was（6.25%）, the difference was obvious（P〈0.05）.CONCLUSION H. pylori infection may have a preventive effect on the grouth of UC, with the severity of the disease increasing, the H. pylori positive rate decreased. In addition, it will be very important to strengthen the follow-up compliance of UC patients.

关 键 词：溃疡性结肠炎 幽门螺杆菌 快速尿素酶试验 组织病理活检 

分 类 号：R574.62[医药卫生—消化系统]