CT引导下射频消融联合EGFR-TKI靶向治疗中晚期非小细胞肺癌的效果及对免疫功能的影响  

Effect of CT-guided radiofrequency ablation combined with EGFR-TKI targeted treatment on immune function of advanced non-small cell lung cancer and its therapeutic efficacy

作　　者：李山岭 王杰 陈素芳 王振兴[1] LI Shanling;WANG Jie;CHEN Sufang;WANG Zhenxing(Department of Oncology,the 371st Central Hospital of Liberation Army,Xinxiang,Henan,453000)

机构地区：[1]解放军第371中心医院肿瘤科,河南新乡453000

出　　处：《实用临床医药杂志》2018年第11期47-50,54,共5页Journal of Clinical Medicine in Practice

基　　金：河南省科技厅科技攻关项目(13210231053)

摘　　要：目的探讨CT引导下射频消融联合EGFR-TKI靶向治疗中晚期非小细胞肺癌(NSCLC)的效果及对免疫功能的影响。方法选取108例中晚期NSCLC患者,将接受射频消融联合GP方案化疗的53例患者作为对照组,将接受射频消融联合EGFR-TKI靶向治疗的55例患者作为观察组。比较2组患者免疫功能指标、生命质量指标等。结果治疗后2组患者CD_3^+、CD_4^+和CD_4^+/CD_8^+ 水平显著升高,CD_8^+ 水平显著下降,且观察组CD_3^+、CD_4^+和CD_4^+/CD_8^+ 水平显著高于对照组,CD_8^+ 水平显著低于对照组(P<0.05)。治疗后观察组IgG、IgM、IgA指标上升,对照组IgG、IgM、IgA指标下降,差异有统计学意义(P<0.05)。治疗后2组患者角色、躯体、情绪、认知、社会功能等指标均显著升高,其中观察组显著高于对照组(P<0.05);2组患者恶心呕吐、疲劳、便秘、腹泻、睡眠障碍、疼痛等指标显著降低,观察组显著低于对照组(P<0.05)。观察组临床治疗总有效率为95.45%,显著高于对照组的45.28%(P<0.05)。观察组治疗后1年、2年生存率均高于对照组(P>0.05)。结论 CT引导下射频消融联合EGFR-TKI靶向治疗能够显著提高中晚期NSCLC患者临床治疗效果,改善免疫功能,提高生命质量。Objective To investigate the effect of CT-guided radiofrequency ablation combined with EGFR-TKI targeted therapy on the treatment of advanced non-small cell lung cancer （NSCLC） and its influence on immune function.Methods A total of 108 middle and late NSCLC patients who were treated in our hospital were be chosen as study objects.A total of 53 patients undergoing radiofrequency ablation combined with GP therapy were selected as control group,while 55 patients undergoing radiofrequency ablation combined with EGFR-TKI targeted therapy were selected as observation group.The immune function index and life quality index of the two groups were compared.Results After treatment,the levels of CD3 ＋,CD4 ＋ and CD4 ＋/CD8 ＋ were increased and CD8 ＋ level was decreased in the two groups,and were significantly higher,and lower,respectively,in observation group than the control group （P ＜ 0.05）.After treatment,the indicators of IgG,IgM and IgA in the observation group were increased,and the IgG,IgM and IgA in the control group were decreased（P ＜ 0.05）.Physical,emotional,cognitive roles,social function and other indicators of two groups were significantly increased,and the observation group was significantly higher than the control group （P ＜ 0.05）.Complications such as Nausea and vomiting,constipation,diarrhea,fatigue,sleep disorder,pain of two groups were decreased significantly,and the observation group was significantly lower than the control group （P ＜ 0.0 5）.The total effective rate of clinical treatment in the observation group was 95.45％,which was significantly higher than 45.28％ of the control group （P ＜ 0.05）.The 1,2-year survival rates after treatment in the observation group were higher than that in the control group,but there was no statistical difference in two groups （P ＞ 0.05）.Conclusion CT-guided radiofrequency ablation combined with EGFR-TKI targeted therapy can significantly improve clinical therapeutic effect,improve immune function and quality of life in

关 键 词：非小细胞肺癌 靶向治疗 射频消融术 免疫功能 

分 类 号：R734.2[医药卫生—肿瘤]