羧基改性PAMAM体内封闭脱矿牙本质小管的效果观察  

Efficacy of carboxyl-terminated polyamidoamine dendrimer on demineralized dentinal tubules occlusion in vivo

作　　者：龙金东 韦小浪 吴柳鲜 李安琳 谢方方[1] Long Jindong;Wei Xiaolang;Wu Liuxian;Li Anlin;Xie Fangfang(Department of Endodontics,College of Stomatology,Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西医科大学附属口腔医院牙体牙髓科,南宁530021

出　　处：《广西医科大学学报》2018年第5期632-635,共4页Journal of Guangxi Medical University

基　　金：国家自然科学基金资助项目(No.81760204)

摘　　要：目的:研究体内评估羧基改性的聚酰胺-胺型树枝状聚合物(PAMAM-COOH)对脱矿牙本质小管的封闭能力。方法 :将部分脱矿人牙本质片对半切开,随机分为A组和B组,分别经PAMAM-COOH和去离子水处理后缝合到大鼠的颊部黏膜侧,在大鼠口腔环境中保留1周、2周、4周后取出样本,采用扫描电子显微镜(SEM)对牙本质片的微观形貌进行检测。结果:PAMAM-COOH处理后的A组牙本质随着时间的推移,小管口逐渐形成矿物沉积物,管径变小,呈封闭趋势;而B组仅有少量沉积物,牙本质小管口呈开放状态。结论:PAMAM-COOH具有诱导脱矿牙本质矿化封闭牙本质小管的作用。Objective：To evaluate the abilities of dentinal tubules occlusion of the carboxyl-terminated polyamidoamine dendrimer（PAMAM-COOH）on human demineralized dentin in vivo.Methods：Demineralization dentin discs were divided into two halves and marked with A and B randomly,which were sutured to the interior side of the rat＇s cheeks after treated with PAMAM-COOH and deionized water,respectively.The samples were harvest at 1,2,and 4 weeks.The microstructure of dentin discs surface were characterized by SEM.Results：The dentinal tubules of the dentin discs treated with PAMAM-COOH were occlusive gradually,whereas just a few depositions existed on the control group,and dentinal tubules remained open.Conclusion：PAMAM-COOH had effects on inducing demineralized dentin mineralize and occlude dentinal tubules.

关 键 词：牙本质过敏症 聚酰胺—胺型树枝状聚合物 生物矿化 

分 类 号：R783.1[医药卫生—口腔医学]