肠道菌群失调诱导肥胖发生发展的机制研究进展  

Mechanism of intestinal microbiota disorder inducing obesity development

作　　者：许文琦 王生 王艳[1,2] 梅其炳 刘莉 XU Wen-qi;WANG Sheng;WANG Yan;MEI Qi-bing;LIU Li(China State Institute of Pharmaceutical Industry, Shanghai 200040;State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, Shanghai 200437;Shanghai Professional and Technical Service Center for Biological Material Druggability Evaluation, Shanghai 200437, China)

机构地区：[1]中国医药工业研究总院,上海200040 [2]上海医药工业研究院创新药物与制药工艺国家重点实验室,上海200437 [3]上海市生物物质成药性评价专业技术服务平台,上海200437

出　　处：《世界临床药物》2018年第6期417-421,共5页World Clinical Drug

基　　金：上海市青年科技扬帆计划项目(编号:17YF1419000)

摘　　要：正常肠道菌群参与营养物质代谢、免疫调节以及神经系统发育等多种重要的生理过程,基因及环境因素改变可引起肠道微生态失衡,进而导致机体多种生理活动紊乱,诱发和促进肥胖及相关代谢综合征的发生发展。肥胖患者罹患糖尿病、心血管疾病及肿瘤等的风险增加。以往对肥胖的认知主要围绕脂肪代谢的机制展开,逆转肠道菌群失调能有效改善肥胖及其相关代谢性疾病,但是对肠道菌群失调介导肥胖发生的机制尚无明确系统的认识,临床上针对改善肥胖尚无理想的药物。本文概述近年来国内外研究肠道菌群失调在肥胖发生发展中的作用机制,以期为调节肠道菌群失调,改善肥胖症状的研究思路提供理论依据。Normal intestinal microbiota is involved in many important physiological processes such as the nutrient metabolism, immune regulation and nervous system development. However, the change of genes and environmental factors can cause intestinal microecological imbalances, which can lead to a variety of physiological activity disorders including obesity development and related metabolic syndromes. The obesity patients have a higher risk of suffering from diabetes, cardiovascular disease, and cancer. In the past, the cognition of obesity mainly revolved around the mechanism of fat metabolism. However, the reversal of intestinal microbiota dysbiosis can effectively improve obesity and related metabolic diseases. Now, the mechanism of intestinal microbiota disorder affected obesity development is still not very clear. This article aims to review the research progress on the mechanism of intestinal microbiota disorder in obesity development, to provide a reference for obesity improvement.

关 键 词：肠道菌群失调 肥胖 发病机制 

分 类 号：R36[医药卫生—病理学]