MiRNAs作为胆管癌诊断标志物的Meta分析  

Meta analysis of miRNAs as a diagnostic marker for cholangiocarcinoma

作　　者：金巍 韩涛[1] 洪欣[1] 孙大军[1] 赵浩民[1] JIN Wei;HAN Tao;HONG Xin;SUN Dajun;ZHAO Haomin(Department of Vascular Surgery ,China-Japan Union Hospital of Jilin University,Changchun,Jilin 130033,China)

机构地区：[1]吉林大学中日联谊医院血管外科,长春130033

出　　处：《重庆医学》2018年第19期2586-2589,2593,共5页Chongqing medicine

摘　　要：目的全面客观地评价微RNAs(miRNAs)在胆管癌早期诊断中的价值。方法采用Meta分析的方法,定量综合统计,利用计算机检索Pubmed、Web of Science、Cochrane Library、中国知网、万方和维普等数据库所有有关miRNAs对胆管癌诊断价值研究的文章,对符合纳入、排除标准的文章,提取数据,使用Stata12.0和Meta-Disc1.4软件进行统计分析。结果 11篇文章纳入本次研究,共包括819例研究对象,病例组439例,对照组380例。结果显示,miRNAs诊断胆管癌的合并灵敏度和特异度分别为0.83[95%CI(0.80,0.87)]和0.85[95%CI(0.81,0.89)],合并的阳性似然比和阴性似然比分别为4.86[95%CI(3.23,7.31)]和0.22[95%CI(0.16,0.29)],诊断比值比为27.49[95%CI(15.30,49.38)],AUC值为0.908 2。结论 MiRNAs诊断胆管癌具有较高的灵敏度和特异度,在胆管癌的早期诊断方面具有较高价值。Objective To comprehensively and objectively evaluate the diagnostic value of microRNAs（miRNAs）for cholangiocarcinoma.Methods The meta analysis method and quantitative comprehensive statistics were adopted.All the articles on the diagnostic value of miRNAs for cholangiocarcinoma were retrieved from PubMed,Web of science,Cochrane Library,CNKI,Wanfang and Vip databases by computer.Then the data were extracted from the articles conforming to the inclusion and exclusion criteria.The Stata 12.0 and Meta-Disk1.4 software were used to conduct the statistics.Results Eleven articles were included in this research,including 439 research subjects,439 cases in the case group and 380 cases in the control group.The results showed that the pooled sensitivity and specificity of miRNAs for diagnosing cholangiocarcinoma were0.83[95%CI（0.80,0.87）]and 0.85[95%CI（0.81,0.89）],and the pooled positive likelihood ratio and negative likelihood ratio were 4.86[95%CI（3.23,7.31）]and 0.22[95%CI（0.16,0.29）],and the pooled diagnostic odds ratio was 27.49[95%CI（15.30,49.38）].In addition,the area under the ROC cure（AUC）was0.908 2.Conclusion MiRNAs has a relatively high sensitivity and specificity for diagnosing cholangiocarcinoma and possesses a higher diagnostic value in early diagnosis of cholangiocarcinoma.

关 键 词：胆管肿瘤 微小RNAS 诊断 META分析 

分 类 号：R735.8[医药卫生—肿瘤]