^(68)Ga-PSMAPET/CT在前列腺癌复发中的应用进展  

Application Progress of ^(68)Ga-PSMA PET/CT in Recurrent Prostate Cancer

作　　者：杨立平[1] 李福兴(综述)[1] 李文贵(审校)[1] YANG Liping;LI Fuxing;LI Wengui(Department of Medical Imaging, Tianjin Baodi Hospital Baodi Clinical College of Tianjin Medical University, Tianjin 301800, China)

机构地区：[1]天津市宝坻区人民医院影像科,天津医科大学宝坻临床学院影像科,天津301800

出　　处：《肿瘤防治研究》2018年第7期505-509,共5页Cancer Research on Prevention and Treatment

摘　　要：前列腺癌(prostate cancer,PCa)发病率高,根治性治疗后,复发病灶的早期诊断对患者的预后至关重要。前列腺特异性膜抗原(prostate specific membrane antigen,PSMA)是一种在PCa中高表达的跨膜糖蛋白,利用核素^(68)Ga标记其小分子抑制剂作为显像剂,进行PET/CT显像,可以得到反映PCa病灶在体内分布的影像。欧美很多国家已经将^(68)Ga-PSMA PET/CT应用于寻找PCa患者复发病灶,并取得了很好的效果,该技术在我国还处于起步阶段。本文综述了多个有关^(68)Ga-PSMA PET/CT在前列腺癌复发中的研究进展,旨在提高我们对该项新技术的认识水平。The morbidity of prostate cancer （PCa） is high. Early diagnosis of recurrence after primary treatment is very important for the prognosis. Prostate specific membrane antigen （PSMA） is a transmembrane glycoprotein, with high expression in PCa. Small molecule inhibitors of the PSMA is labeled by 68Ga（68Ga-PSMA）. 68Ga-PSMA is used as imaging agent for PET/CT imaging. 68Ga-PSMA PET/CT can display the distribution of prostate cancer in vivo. Many European and American countries have used 68Ga-PSMA PET/CT to find recurrent lesions in prostate cancer patients and achieved good results. This technology is still in its initial stage in China. This article reviews the research progress of 68Ga-PSMA PET/CT in prostate cancer recurrence, in order to improve the understanding of this new technology in China.

关 键 词：前列腺肿瘤 复发 68Ga-PSMA PET/CT 

分 类 号：R737.25[医药卫生—肿瘤]