尿酸在糖尿病视网膜病变中的作用研究现状及进展  

The roles of uric acid in the pathogenesis of diabetic retinopathy

作　　者：佘新平 朱丹丹 郑志[1] She Xinping;Zhu Dandan;Zheng Zhi(Department of Ophthalmology, The First People＇s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai 200080, Chin)

机构地区：[1]上海交通大学附属第一人民医院眼科 上海市眼底病重点实验室 上海市眼视觉及光医学工程研究中心,200080

出　　处：《中华眼底病杂志》2018年第4期401-404,共4页Chinese Journal of Ocular Fundus Diseases

基　　金：国家自然科学基金面上项目（81770947）

摘　　要：尿酸（UA）是人体嘌呤分解代谢的终产物，作为体内的主要抗氧化剂之一，可清除氧自由基。但在氧化-抗氧化穿梭机制作用下，UA的抗氧化性可被逆转，引起血管内皮细胞氧化应激，诱导炎症反应。高UA血症（HUA）被认为是糖尿病及其并发症糖尿病肾病的主要危险因素之一，HUA和糖尿病视网膜病变（DR）的研究也备受关注；UA有致视网膜血管硬化的作用，通过促进氧化应激、诱导新生血管形成等机制影响DR的发生发展。Uric acid （UA） is the final product of human purine metabolism. As one of the main antioxidants in the body, it can scavenge oxidative radicals. Under the action of oxidative-antioxidant shuttle mechanism, the antioxidant activity of UA can be reversed, causing inflammation and oxidative stress of vascular endothelial cells. Hyperuricemia （HUA） is considered to be one of the major risk factors for diabetes and diabetic nephropathy. The study of HUA in diabetic retinopathy （DR） is also a hot topic. UA can cause retinal vascular sclerosis, and affect the occurrence and development of DR by promoting oxidative stress and inducing neovascularization.

关 键 词：尿酸 糖尿病视网膜病变 高尿酸血症 综述 

分 类 号：R774.1[医药卫生—眼科] R587.26[医药卫生—临床医学]