羌活-独活在外用药活血散中的作用  

Efficacy of a Pair of Notopterygii Rhizoma et Radix-Angelicae Pubescentis Radix in External Use

作　　者：沈鸿[1] 穆兰澄[2] 汪芳[1] 谢利民[2] SHEN Hong;MU Lan-cheng;WANG Fang;XIE Li-min(Institute of Chinese Materia Medica, China Academy of Chinese Medicinal Sciences, Beijing 100700, China;Guang＇anmen Hospital, China Acabemy of Chinese Medical Sciences, Beijing 100053, China)

机构地区：[1]中国中医科学院中药研究所,北京100700 [2]中国中医科学院广安门医院,北京100053

出　　处：《中国实验方剂学杂志》2018年第15期228-234,共7页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：北京市科学技术课题项目(Z161100001816017)

摘　　要：活血散是广安门医院名老中医杜自明老先生的祖传验方,主要功效为温经散寒祛湿,活血消肿止痛,临床上广泛用于膝骨关节炎（KOA）的治疗,疗效显著。羌活-独活作为治疗膝骨关节炎病的常用药,是活血散的重要组成之一。本文以＂羌活＂＂独活＂为主要检索词,对近10年来有关羌活-独活药对的研究文献进行检索,保留与本文相关的文献,对羌活-独活的药性、临床及药理研究进行回顾和总结分析。文献总结分析显示,（1）羌活-独活能祛风除湿、温经散寒、通痹止痛,为治疗膝骨关节炎病的有效药对之一,其临床治疗的总有效率均在80%以上,治疗效果显著;（2）羌活-独活配伍应用,二药相须相助增强药力,临床疗效明显高于其单独应用;分析这可能与联用后其挥发油变化,种类、数目的增多,新成分的产生有关,印证了羌活-独活配伍应用的治疗效果强于单独给药的合理性;（3）羌活-独活外用治疗膝骨关节炎疗效可靠。由于羌活-独活含有较高的、适合于透皮吸收的挥发油,故适合用于外敷、外用,具有局部药物浓度高、起效快的特点。羌活-独活所具有的这些独特药性,在活血散的临床上起着重要作用,成为活血的重要组成成分。活血散处方具有安全、有效、方便的特性。随着药源性疾病问题的日益突出,中医外治法越来越受到国内外学者专家的高度重视。Huoxue powder is a proved recipe of Mr. Du Zi-ming,a famous veteran doctor of traditional Chinese medicine（TCM） at Guang＇anmen Hospital. The main effect is to warm channels to dispel cold dampness,promote blood circulation and relieve pain. In clinic,it is widely applied in treating knee osteoarthritis（KOA） and other relevant diseases,with a good efficacy. Notopterygii Rhizoma et Radix-Angelicae Pubescentis Radix are commonly used drugs for the treatment of osteoarthritis of the knee,and important components of Huoxue powder.With Notopterygii Rhizoma et Radix and Angelicae Pubescentis Radix as the key words, the authors retrieved relevant research literatures over the past ten years,and retain the literatures related to this article. The clinical and pharmacological studies of Notopterygii Rhizoma et Radix-Angelicae Pubescentis Radix were reviewed and summarized for analysis. According to the summary and analysis of the literatures,（1） Notopterygii Rhizoma et Radix and Angelicae Pubescentis Radix can dispel wind and dehumidification,warm meridian and relieve cold and relieve pain,and are effective drugs for the treatment of osteoarthritis of knee. The total effective rate of clinical treatment was above 80%,and the curative effect was remarkable.（2） The combined application of Notopterygii Rhizoma et Radix and Angelicae Pubescentis Radix could help enhance the efficacy,so the clinical efficacy was significantly higher than the single application. The cause may be related to the changes in volatile oil,such as the increase in species and number,and the appearance of new components. This proved that the effect of combined application was better than that of single application.（3） Effect of Notopterygii Rhizoma et Radix and Angelicae Pubescentis Radix topical in the treatment of knee osteoarthritis is reliable. Because Notopterygii Rhizoma et Radix and Angelicae Pubescentis Radix contain high content of volatile oil that is suitable for transdermal absorption,it is suitable for external use. No

关 键 词：药对 活血散 羌活-独活 外用 膝骨关节炎 

分 类 号：R22[医药卫生—中医基础理论] R242[医药卫生—中医学]