甘孜藏族自治州首次痫性发作住院患者临床特征回顾性分析  

Clinical features of in-patients with first seizure in Ganzi Tibetan Autonomous Prefecture: a retrospective analysis

作　　者：何永桥 陈佳妮[2] 李思思 邓永宜 陈洁 方文彧 泽仁扎姆 慕洁[2] 周东[2] HE Yongqiao;CHEN Jiani;LI Sisi;DENG Yongyi;CHEN Jie;FANG Wenyu;ZEREN Zhamu;MU Jie(Department of Neurology,Ganzi Tibetan Autonomous Prefecture People＇s Hospital,Ganzi Tibetan Autonomous Prefecture,626000 China;Department of Neurology,West China Hospital of Sichuan University,Chengdu,610041,China)

机构地区：[1]四川省甘孜藏族自治州人民医院神经内科,甘孜626000 [2]四川大学华西医院神经内科,成都610041

出　　处：《癫痫杂志》2018年第3期214-219,共6页Journal of Epilepsy

基　　金：国际癫痫病友会"Promising Strategies Program"(HX-H1711139)

摘　　要：目的研究旨在为甘孜藏族自治州癫痫发作提供临床特征的数据,以改善该地区的癫痫发作防治策略。方法研究回顾性分析了甘孜藏族自治州人民医院神经内科2015年1月–2017年10月期间收治的因首次发作入院的癫痫患者的临床记录,总结其临床特点。结果研究共纳入101例患者,平均年龄(43.0±18.4)岁。29例因癫痫持续状态入院,其中5例(17.2%)在入院后的30 d内死亡。45例为急性症状性癫痫发作,颅内感染是最常见的诱因(n=22,48.9%),其中包括脑囊虫(n=4,8.9%)、结核感染(n=8,17.7%),病毒感染(n=7,15.6%)和其他(n=3,6.7%)。其他诱因包括脑血管疾病(n=13,28.8%),高原反应(n=3,6.7%),酒精相关或急性戒断综合症(n=3,6.7%)和其他原因(n=3,6.7%)。结论在甘孜藏族自治州,控制颅内感染对预防和控制急性癫痫的急性症状性发作较为重要。对当地基层医生进行癫痫持续状态诊治的培训将有助于更好地管理该地区癫痫发作。Objective This study aimed to provide data about the clinical features of first seizure in the Ganzi Tibetan Autonomous Prefecture to improve the strategies for epilepsy prevention and control in this region.Methods We reviewed the clinical record of patients with first seizure in Neurology Department,Ganzi Tibetan Autonomous Prefecture People’s Hospital between January 2015 and October 2017 and summarised their clinical features.Results One hundred and one patients were included in this study with the average age of（43.0±18.4）years.Twenty-nine cases were diagnosed as statusepilepticus,5（17.2%）of whom died in 30 days.Among the 45 patients diagnosed with acute symptomatic seizure,22 cases（48.9%）were caused by cerebral infection,including neurocysticercosis（n=4,8.9%）,tuberculous infection（n=8,17.7%）and viral infection（n=7,15.6%）.Other causes of acute symptomatic seizure included cerebrovascular diseases（n=13,28.8%）,high altitude（n=3,6.7%）and alcohol related or alcohol withdrawl（n=3,6.7%）.Conclutions These data suggest that the control of cerebral infections is essential for the prevention and treatment of seizures in the Ganzi Tibetan Autonomous Prefecture.Education of local primary doctors about status epilepticus will enable better management of seizures in this population.

关 键 词：癫痫管理 颅内感染 回顾性研究 甘孜藏族自治区 

分 类 号：R742.1[医药卫生—神经病学与精神病学]