碳离子束辐照处理对牛至精油微胶囊的缓释特性及抗鸡球虫病活性的影响  

Effect of Using Carbon-ion Beam Irradiation on Sustained-release Characteristic and Anti-coccidial Activity of Oregano Essential Oil Microcapsules

作　　者：陶蕾[1,2] 梁妍 周翔[4] 姜婷婷[4,5] 李雪虎 衣云鹏[6] 辛志君 陆锡宏[4] 赵凤舞[2] 崔燕[1] 梁剑平[1,4,6] TAO Lei;LIANG Yan;ZHOU Xiang;JIANG Tingting;LI Xuehu;YI Yunpeng;XIN Zhijun;LU Xihong;ZHAO Fengwu;CUI Yah;LIANG Jianping(College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China;Lanzhou Vocational Technical College, Lanzhou 730070, China;School of Pharmacy, Lanzhou University, Lanzhou 730000, China;Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;University of Chinese Academy of Sciences, Beijing 100049, China;Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China)

机构地区：[1]甘肃农业大学,兰州730070 [2]兰州职业技术学院,兰州730070 [3]兰州大学药学院,兰州730070 [4]中国科学院近代物理研究所,兰州730000 [5]中国科学院大学,北京10049 [6]中国农业科学院兰州畜牧与兽药研究所,兰州730050

出　　处：《原子核物理评论》2018年第2期179-188,共10页Nuclear Physics Review

基　　金：甘肃省国际科技合作项目(1504WKCA098);兰州市科技计划项目(2016-3-101);甘肃省自然科学基金项目(1506RJZA293);中国科学院西部之光人才培养引进计划-"西部青年学者"A类项目(Ke-Fa-Ren-Zi[2015]No.77);中国农业科学院2018年重大产出科研选题项目(CAAS-ZDXT2018008);甘肃省中药材产业体系项目~~

摘　　要：利用不同剂量的碳离子束辐照处理牛至精油微胶囊,研究对其缓释特性及抗鸡球虫病活性的影响。研究结果表明,通过碳离子束处理的牛至精油微胶囊,其主要活性成分百里香酚和香芹酚含量未发生变化,辐照处理后反应收率及产品的生物活性均提高,其中400 Gy剂量处理的牛至精油微囊的收率和生物活性均最高,收率达68.44%。通过对感染柔嫩艾美耳球虫的小鸡喂食后,其盲肠和十二指肠肿胀明显减轻,血液性内容物明显减少,血便指数在感染的第七天已降为0,抗球虫指数(ACI)达到179.39。The purpose of this study is using different doses of carbon ion beam irradiation on oregano essential oil microcapsules, to investigate function of control release and anticoccidial activity in chickens. The results showed that the content of main components in oregano essential oil microcapsules after carbon ion beam irradiation, thymol and carvacrol, have little change. Moreover, it can obtain more object products and better bioactivity after the irradiation treatment. Among these different doses of irradiation, our findings showed that Microcapsule groups with 400 Gy dose irradiation showed the highest yield（68.44 %） and the best anticoccidial activity. After feeding chickens infected with Eimeria tenella, the swelling of caecum and duodenum were significantly mitigated and blood contents were also significantly reduced. The bloody stool index of chickens was as low as zero on the seventh day of infection, and the anticoccidial index（ACI） is 179.39.

关 键 词：碳离子 牛至精油 微胶囊 柔嫩艾美耳球虫 

分 类 号：Q691[生物学—生物物理学]