HNF1B基因多态性与前列腺癌发病风险相关性的Meta分析  

The association between the variants of HNF1B gene and the risk of prostate cancer: a meta-analysis

作　　者：马玉姗 江晓琴 倪娟 童煜[2,3] MA Yushan;JIANG Xiaoqing;NI Juan;TONG Yu(Department of Anesthesiology,West China Second Hospital,Sichuan University,Chengdu,610041,P.R.China;Department of Pediatrics,West China Second Hospital,Sichuan University,Chengdu,610041,P.R.China;Key Laboratory of Birth Defects and Related Diseases of Women and Children,Sichuan University,Chengdu,610041,P.R.China)

机构地区：[1]四川大学华西第二医院麻醉科,成都610041 [2]出生缺陷与相关妇儿疾病教育部重点实验室,成都610041 [3]四川大学华西第二医院西部妇幼医学研究院,成都610041

出　　处：《中国循证医学杂志》2018年第7期662-669,共8页Chinese Journal of Evidence-based Medicine

摘　　要：目的系统评价HNF1B基因多态性与前列腺癌发病风险的相关性。方法计算机检索Pub Med、EMbase、The Cochrane Library、CNKI、CBM和Wan Fang Data数据库,搜集有关HNF1B基因多态性与前列腺癌发病风险相关性的病例-对照研究,检索时限均从建库至2017年12月。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Stata 14.0软件进行Meta分析。结果共纳入15个病例-对照研究,包括病例组30 532例、对照组38 832例。Meta分析结果显示,HNF1B基因rs4430796多态性[G vs.A:OR=0.802,95%CI(0.784,0.821),P<0.001;GG vs.AA:OR=0.659,95%CI(0.606,0.717),P<0.001;AG vs.AA:OR=0.762,95%CI(0.714,0.814),P<0.001)],rs11649743多态性[A vs.G:OR=0.875,95%CI(0.820,0.941),P<0.001;AA vs.GG:OR=0.669,95%CI(0.564,0.792),P<0.001;AG vs.GG:OR=0.855,95%CI(0.798,0.916),P<0.001)];rs7501939多态性[A vs.G:OR=0.833,95%CI(0.807,0.859),P<0.001],rs3760511多态性[A vs.C:OR=0.834,95%CI(0.803,0.868),P<0.001]均与前列腺癌发病风险存在显著相关性。结论当前证据表明,HNF1B基因多态性与前列腺癌发病风险存在显著相关性。受纳入研究数量和质量的限制,上述结论尚待更多高质量研究予以验证。Objectives To systematically review the association between the variants of HNF1B gene and the risk of prostate cancer. Methods Pub Med, EMbase, The Cochrane Library, CNKI, CBM and Wan Fang Data databases were electronically searched to collect case-control studies on the association between the variants of HNF1B gene and risk of prostate cancer from inception to December, 2017. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Meta-analysis was then performed using Stata 14.0 software. Results A total of 15 case-control studies involving 30 532 patients and 38 832 controls were included. The results of meta-analysis showed that： there was a strong significant association between rs4430796 variants（G vs. A： OR=0.802, 95%CI 0.784 to0.821, P〈0.001; GG vs. AA： OR=0.659, 95%CI 0.606 to 0.717, P〈0.001; AG vs. AA： OR=0.762, 95%CI 0.714 to 0.814,P〈0.001）, rs11649743 variants（A vs. G： OR=0.875, 95%CI 0.820 to 0.941, P〈0.001; AA vs. GG： OR=0.669, 95%CI 0.564 to0.792, P〈0.001; AG vs. GG： OR=0.855, 95%CI 0.798 to 0.916, P〈0.001）, rs7501939 variants（A vs. G： OR=0.833, 95%CI0.807 to 0.859, P〈0.001）, rs3760511 variants（A vs. C： OR=0.834, 95%CI 0.803 to 0.868, P〈0.001） and risk of prostate cancer. Conclusions Current evidence shows that HNF1B gene variants are associated with risk of prostate cancer. Due t o limited quantity and quality of the included studies, more high quality studies are required to verify the above conclusion.

关 键 词：HNF1B 基因多态性 前列腺癌 META分析 系统评价 病例-对照研究 

分 类 号：R737.25[医药卫生—肿瘤]