北京地区口腔鳞状细胞癌患者并存疾病的初步研究  

Comorbidity in oral squamous cell carcinoma patients： an initial research in Beijing area

作　　者：高柳[1] 毛驰[2] 俞光岩[2] 彭歆[2] Gao Liu;Mao Chi;Yu Guangyan;Peng Xin(Second Clinical Division,Peking University School and Hospital of Stomatology ＆ National Clinical Research Center for Oral Diseases ＆ National Engineering Laboratory for Digital and Material Technology of Stomatology ＆ Beijing Key Laboratory of Digital Stomatology,Beijing 100101,China;Department of Oral and Maxillofacial Surgery,Peking University School and Hospital of Stomatology ＆ National Clinical Research Center for Oral Diseases ＆ National Engineering Laboratory for Digital and Material Technology of Stomatology ＆ Beijing Key Laboratory of Digital Stomatology,Beijing 100081,Chin)

机构地区：[1]北京大学口腔医学院·口腔医院第二门诊部国家口腔疾病临床医学研究中心口腔数字化医疗技术和材料国家工程实验室口腔数字医学北京市重点实验室,100101 [2]北京大学口腔医学院·口腔医院口腔颌面外科,100101

出　　处：《中华口腔医学杂志》2018年第7期433-436,共4页Chinese Journal of Stomatology

摘　　要：目的调查北京地区口腔鳞状细胞癌（oral squamous cell carcinoma，OSCC）患者的并存疾病状况，探讨并存疾病与中外OSCC患者预后的关系，以期为临床提供参考。方法收集2007年1月至2009年12月于北京大学口腔医学院·口腔医院就诊的313例北京地区OSCC患者信息，使用成人并存疾病评价指数27条目中文简体版记录并存疾病情况。使用Cox多元回归分析研究患者年龄、性别、TNM分期、并存疾病分级与术后生存率是否相关。结果TNM分期、并存疾病分级对术后生存率是影响OSCC生存率的独立因素。本研究中无、轻度、中度、重度并存疾病患者比例分别为24%、48%、18%、10%。中度与重度并存疾病患者的5年生存率分别为50%（29/58）和13%（4/30）。结论并存疾病信息有助于评估OSCC患者整体健康状况，建议使用并存疾病信息完善OSCC患者的临床分期与整体评估。ObjectiveTo make a preliminery research of comobidity in oral squamous cell carcinoma （OSCC） patients who resides in Beijing area and investigate whether comorbidity affect the surviving rate independently. Compare the similarities and differences between Chinese and foreign OSCC patients.MethodsThe medical records of 313 patients who undertaken operation in Peking University Stomatology School from January 2007 to Delember 2009 were retrospectively reviewed. Adult comorbidity evaluation-27 Chinese edition index was used to estimate the comorbidity severity. COX proportional hazards model was used to analyze whether the TNM stage, comobidity, age and gender affected 5-year survival rate.ResultsTNM stage and comorbidity have a significant impact on survival rate, the postoperative survival rate decreased significantly with the increasing level of TNM staging and the complexity of comorbidity disease. In this study, the proportion of patients with none, mild, moderate and severe comorbidity diseases was 24%, 48%, 18% and 10%. The five-year survival rates of patients with moderate and severe comorbidity disease were 50% （29/58） and 13% （4/30） respectively.ConclusionsThe comorbidity disease information can help assess the overall health of OSCC patients, and it is recommended to improve the clinical staging and overall evaluation of oral cancer patients with comorbidity disease information.

关 键 词：口腔肿瘤 预后 肿瘤分期 并存疾病 

分 类 号：R739.8[医药卫生—肿瘤]