甲基化在鼻咽癌中的研究进展  

Research Progress of Methylation in Nasopharyngeal Carcinoma

作　　者：卢志伟 尹丽[1] 何侠[1] LU Zhi-wei;YIN Li;HE Xia(Jiangsu Cancer Hospital,Jiangsu Institute of Cancer Research,Nanjing Medical University Affiliated Cancer Hospital,Nanjing 210009,China)

机构地区：[1]江苏省肿瘤医院江苏省肿瘤防治研究所南京医科大学附属肿瘤医院

出　　处：《肿瘤学杂志》2018年第6期531-535,共5页Journal of Chinese Oncology

基　　金：江苏省科技厅临床医学重点专项(BL2014091)

摘　　要：尽管目前鼻咽癌治疗已有较大进展,但局部复发或远处转移仍然经常发生。因此探索早期诊断和预后的有效生物标志物及发现新的治疗靶点十分关键。DNA甲基化是表观遗传学的重要研究内容之一,鼻咽癌的发病过程往往伴随着DNA甲基化的异常。全文总结关于鼻咽癌相关基因甲基化的研究,并对目前DNA甲基化在鼻咽癌相关基因甲基化、早期诊断、预后及治疗中的作用进行讨论。Although there has been considerable progress in the treatment of nasopharyngeal carcinoma,local recurrence or distant metastasis is still frequent. Therefore,it is critical to explore effective biomarkers for early diagnosis and prognosis and to discover new therapeutic targets. DNA methylation is one of the important research contents of epigenetic. The pathogenesis of nasopharyngeal carcinoma is often accompanied by abnormal DNA methylation. The study of methylation of nasopharyngeal carcinoma related genes were summarized in this review,and discusses the role of DNA methylation in the methylation,early diagnosis,prognosis and treatment of nasopharyngeal carcinoma related genes

关 键 词：鼻咽肿瘤 DNA甲基化 鼻咽癌相关基因 预后 治疗 

分 类 号：R739.63[医药卫生—肿瘤]