医用臭氧水治疗鼻咽癌放射性口腔溃疡的临床效果  

Clinical effect of medical ozone water in the treatment of radioactive oral ulcer of nasopharyngeal carcinoma

作　　者：胡建锋 洪顺垣 郑广良 HU Jian-feng;HONG Shun-yuan;ZHENG Guang-liang(Department of Oncology,Shunde Hospital of Guangzhou Traditional Chinese Medical University,Guangdong Province,Foshan 528333,China;Department of Pain,Shunde Hospital of Guangzhou Traditional Chinese Medical Universi- ty,Guangdong Province,Foshan 528333,China)

机构地区：[1]广州中医药大学顺德医院肿瘤科,广东佛山528333 [2]广州中医药大学顺德医院疼痛科,广东佛山528333

出　　处：《中国当代医药》2018年第20期60-62,共3页China Modern Medicine

基　　金：广东省佛山市医学类科技攻关项目(201308294)

摘　　要：目的探讨臭氧水对放射性口腔溃疡的治疗效果。方法选取我院2015年7月~2017年6月行同期放化疗或放疗的鼻咽癌患者,出现口腔溃疡的40例患者作为研究对象,采用随机数字表法将其分为对照组、实验组,每组20例。实验组患者使用自配维生素B_(12)溶液(0.9%氯化钠500 ml+维生素B_(12)2500μg)含漱,每次10 min,4次/d,臭氧水(浓度15μg/L)含漱,每次10 min,2次/d。对照组患者予维生素B_(12)溶液含漱,每次10 min,8次/d。含漱治疗7 d后,评估疗效。结果治疗7 d后,实验组患者的总有效率显著高于对照组,差异有统计学意义(P<0.05);实验组患者出现轻微恶心2例,未出现呕吐;对照组患者未出现恶心呕吐。两组患者均未出现过敏、中毒等不良反应,差异无统计学意义(P>0.05)。结论臭氧水价格便宜,治疗放射性口腔溃疡安全有效,性价比高,可以作为一个新的治疗方法。Objective To investigate the therapeutic effect of ozonated water on radiation-induced oral ulcer. Methods Forty nasopharyngeal carcinoma patients who underwent concurrent chemoradiotherapy or radiotherapy from July 2015 to June 2017 in our hospital were selected as the research objects. They were divided into control group and experimental group with 20 cases in each group by random number table method. Patients in the experimental group were rinsed with self-made Vitamin B_（12） solution（0.9 % sodium chloride 500 ml ＋ Vitamin B_（12）, 500 μg） for 10 min, 4 times/d, and ozonated water（concentration：15 μg/L） for 10 min, 2 times/d respectively. Patients in the control group were gargled with Vitamin B_（12） solution for 10 min and 8 times/d each time. After 7 days of gargle treatment, the curative effect was evaluated. Results After 7 days of treatment,the total effective rate in the experimental group was significantly higher than that in the control group（P〈0.05）. Two patients in the experimental group showed slight nausea and no vomiting.No nausea or vomiting occurred in the control group. The patients of two groups had not any adverse reactions such as allergy or poisoning, and the difference was not statistically significant（P〉0.05）. Conclusion Ozone water is cost-effective,safe and effective in the treatment of radioactive oral ulcers, which can be used as a new treatment method.

关 键 词：臭氧水 放射性口腔溃疡 鼻咽癌 

分 类 号：R781.5[医药卫生—口腔医学]