原发性开角型青光眼相关基因单核苷酸多态性研究进展  

Research progression of primary open angle glaucoma associated gene single nucleotide polymorphisms

作　　者：蔡晖[1] 王永强[2] CAI Hui;WANG Yong-qiang(Department of ophthalmology,Huangshi Second Hospital of Hubei Province,Huangshi 435000,Chin;Department of ophthalmology,The General Hospital of Jinan Military Region,Jinan 250031,China)

机构地区：[1]湖北省黄石市第二医院眼科,435000 [2]济南军区总医院眼科

出　　处：《中国斜视与小儿眼科杂志》2018年第2期F0003-F0003,I0002,共2页Chinese Journal of Strabismus & Pediatric Ophthalmology

摘　　要：原发性开角型青光眼(POAG)是青光眼的重要类型,研究发现POAG的危险因素主要包括种族、年龄、高度近视、糖尿病、高血压及吸烟史等。最近研究表明一些基因单核苷酸多态性与POAG的发病密切相关。目前关于POAG基因多态性的研究引起了越来越多的学者重视,一些基因多态性位点有望成为POAG防治新的分子靶点,本文拟对POAG相关基因单核苷酸多态性研究进行综述。Primary open angle glaucoma （POAG） is an important type of glaucoma. Race, age, high myopia, diabetes, hypertension and smoking history are the risk factors of POAG. Recent studies have shown that gene single nucleotide polymorphisms is closely related to the incidence of POAG. At present, more and more scholars pay attention to the genetic polymorphism of POAG, some polymorphism loci are expected to be new biomarkers in POAG prevention. This review will summarize the single nucleotide polymorphisms of related genes on POAG.

关 键 词：青光眼 原发性开角型青光眼 基因 单核苷酸多态性 

分 类 号：R775.2[医药卫生—眼科]