康艾注射液辅助化疗治疗大肠癌的meta分析  

A meta-analysis of Kangai injection combined with chemotherapy in treating colorectal cancer

作　　者：张维晴 吴驻林 何力[1] 彭立生[2] Zhang Weiqing;Wu Zhulin;He Li;Peng Lisheng(Department of Oncology,Fourth Clinical Medical College,Guangzhou University of Traditional Chinese Medicine,Shenzhen 518033,China)

机构地区：[1]广东省深圳市中医院肿瘤,518033 [2]广东省深圳市中医院科教科,518033

出　　处：《国际中医中药杂志》2018年第7期616-621,共6页International Journal of Traditional Chinese Medicine

基　　金：深圳市科技计划项目（JCYJ20150401163247231）

摘　　要：目的 系统评价康艾注射液辅助化疗治疗大肠癌的临床效果及安全性。方法 计算机检索中国学术期刊全文数据库（CNKI）、万方数据库、维普数据库（VIP）、中国生物医学文献服务系统（SinoMed）、PubMed、Cochrane图书馆，各库建库至2017年8月17日的有关康艾注射液辅助化疗治疗大肠癌的RCT研究，手工检索作为补充。依据改良后的Jadad量表对纳入文献进行质量评价并提取数据，采用Review Manager 5.3软件进行meta分析。结果 共纳入文献21篇，受试者1 879例。结果提示，试验组干预措施可改善生活质量[OR＝3.29，95% CI（2.53～4.27），P＜0.01]，提高近期疗效[OR＝1.79，95% CI（1.36～2.37），P＜0.01]；减少胃肠道反应[OR＝0.36，95% CI（0.29～0.45），P＜0.01]，减少骨髓抑制反应[OR＝0.35，95% CI（0.27～0.44），P＜0.01]，减少周围神经毒性[OR＝0.57，95% CI（0.41～0.78），P＜0.01]，改善肝功能异常[OR＝0.41，95% CI（0.26～0.65），P＜0.01]，改善肾功能异常[OR＝0.55，95% CI（0.31～0.98），P＝0.040]。结论 康艾注射液辅助化疗治疗大肠癌的临床效果优于单纯化疗，但需要更多高质量RCT结果支持研究结论。Objective To evaluate the therapeutic effect and safety of Kangai injection combined with Chemotherapy in treating Colorectal cancer. Methods The CNKI, Wanfang, CBM, VIP, Medline and Cochrane Library from inception to the August 17th 2017 were searched, and all the relevant journals, and the literature of RCTs were enrolled. The quality of RCTs was assessed by Jadad scores, meta-analyses were performed by Review Manager 5.3 software. Results 21 Chinese articles were enrolled, including three high quality article, and the Jadad average score is 2.7. 1 879 patients were included. The result of Meta-analyses showed that intervention could improve the quality of life [OR=3.29, 95% CI （2.53-4.27）, P〈0.01]; improve the short-term effects [OR=1.79, 95% CI （1.36-2.37）,P〈0.001]; reduce the gastrointestinal reactions [OR=0.36,95% CI （0.29-0.45）, P〈0.01], reduce bone marrow suppression reaction [OR=0.35, 95% CI （0.27-0.44）,P〈0.01]. reduce the peripheral neurotoxicity [OR=0.57, 95% CI （0.41-0.78）, P〈0.01], improve the abnormal liver function [OR=0.0.41,95% CI （0.26-0.65）, P〈0.01], and improve the abnormal renal function [OR=0.55,95% CI （0.31-0.98）, P=0.04]. Conclusions The combination of Kangai injection and Chemotherapy in treating Colorectal cancer is better than only using chemotherapy. However, we need more high-quality RCTs to improve the research.

关 键 词：肠肿瘤 康艾注射液 化疗 注射剂(中药) META分析 

分 类 号：R735.34[医药卫生—肿瘤]