对血清及胸腔积液中细胞因子和肿瘤标志物进行检测在鉴别诊断良恶性胸腔积液中的价值  

The value of detection of cytokines and tumor markers in serum and pleural effusion in differential diagnosis of benign and malignant pleural effusion

作　　者：章志华[1] 栗爱珍[1] 杨永辉[1] 安晓颖[1] 李幸彬[1] Zhang zhihua;Li aizhen;Yang yonghui;An xiaoying;Li xingbin(Hebei Thoracic Hospital,Shijiazhuang,Hebei 050041)

机构地区：[1]河北省胸科医院,河北石家庄050041

出　　处：《当代医药论丛》2018年第10期194-195,共2页

基　　金：河北省卫计委重点科研计划项目青年科技课题(1120140203)

摘　　要：目的:探讨对血清及胸腔积液中细胞因子和肿瘤标志物进行检测在鉴别诊断良恶性胸腔积液中的价值。方法:选取2015年1月至2017年11月期间河北省胸科医院收治的46例结核性胸膜炎患者和44例肺癌患者作为研究对象。将其中的46例结核性胸膜炎患者设为结核组,将其中的44例肺癌患者设为肺癌组。检测两组患者血清及胸腔积液中的瘦素(LEP)、肿瘤坏死因子-α(TNF-α)、癌胚抗原(CEA)、白介素-6(IL-6)及C-反应蛋白(CPR)的水平。然后比较两组患者的检测结果。结果:检测的结果显示,肺癌组患者血清和胸腔积液中LEP、TNF-α、CEA的水平均高于结核组患者,其血清和胸腔积液中IL-6的水平均低于结核组患者(P<0.05)。两组患者血清和胸腔积液中CPR的水平相比差异均无统计学意义(P>0.05)。结论:检测胸腔积液患者血清和胸腔积液中的细胞因子和肿瘤标志物,可有效地鉴别其胸腔积液的性质。Objective： To evaluate the value of serum and pleural effusion cytokines and tumor markers in the identification of tuberculosis and malignant tumors. Methods： Select 46 cases of patients with tuberculous pleurisy treated in Hebei Thoracic Hospital during January 2015 to November 2017 for research object. According to the type of disease, the cases were divided into tuberculosis group（46 cases） and lung cancer group（44 cases）.To detect the serum and pleural effusion cytokines and tumor markers（LEP, TNF-α, CEA, IL-6, CPR） levels of 2 groups of patients. Results： The levels of LEP, TNF-α, CEA of lung cancer group are higher than that in tuberculosis group（P〈 0.05） The IL-6 in serum and pleural effusion of lung cancer group is lower than that in tuberculosis group（P〈 0.05）.The CPR level of 2 groups have no significant difference（P〉 0.05）. Conclusion： The detection of cytokines and tumor markers in serum and pleural effusion of patients with tuberculosis and malignant tumors will identify property of pleural effusion.

关 键 词：肿瘤标志物 细胞因子 血清 胸腔积液 结核性胸膜炎 肺癌 

分 类 号：R735[医药卫生—肿瘤]