加味香砂六君子汤防治大肠癌术后化学治疗患者复发转移临床观察  

Clinical Effect of Jiawei Xiangsha Liujunzi Decoction in Prevention and Treatment of Recurrence and Metastasis in Patients Receiving Chemotherapy after Surgery for Colorectal Cancer

作　　者：仝欣[1] 李敏[1] 徐川[1] 于小伟[1] 方美花[1] 陶智会[1] TONG Xin;LI Min;XU Chuan;YU Xiao-wei;FANG Mei-hua;TAO Zhi-hui(Department of Oncology,Jiading Hospital of Traditional Chinese Medicine,Shanghai 201800,China)

机构地区：[1]上海市嘉定区中医医院肿瘤科,上海201800

出　　处：《安徽中医药大学学报》2018年第3期20-23,共4页Journal of Anhui University of Chinese Medicine

基　　金：上海市嘉定区卫生和计划生育委员会中医药科研项目(2014-KY-ZYY-01);上海市嘉定区中医医院重点专科建设项目(2012-ZD02);上海市嘉定区中医医院李敏中医工作室建设项目(ZYGZS-07)

摘　　要：目的观察加味香砂六君子汤对大肠癌术后化学治疗患者复发转移的影响。方法 2014年9月至2015年9月,共纳入78例大肠癌术后患者,将其随机分为治疗组和对照组,每组39例。对照组采取常规化学治疗方案,至少连用6个周期;治疗组在常规化学治疗基础上口服加味香砂六君子汤。随访2年,主要终点为大肠癌术后复发转移,次要终点为任何原因导致的死亡。用Kaplan-Meier法分析各组大肠癌术后累计生存率的差异。结果与对照组比较,治疗组具有较高的1年累计无病生存率(97.44%vs 94.87%,P=1.000)和显著升高的2年累计无病生存率(92.31%vs 71.79%,P=0.018),治疗组无疾病进展生存期明显延长(P=0.021)。结论加味香砂六君子汤能降低大肠癌术后化学治疗患者复发转移率,显著提高患者的术后生存期。Objective To investigate the clinical effect of Jiawei Xiangsha Liujunzi Decoction in the prevention and treatment of recurrence and metastasis in patients receiving chemotherapy after surgery for colorectal cancer. Methods A total of 78 patients who underwent surgery for colorectal cancer were enrolled from September 2014 to September 2015 and randomly divided into treatment group and control group, with 39 patients in each group. The patients in the control group were given conventional chemotherapy for at least six consecutive cycles, and those in the treatment group were given oral Jiawei Xiangsha Liujunzi Decoction in addition to the conventional chemotherapy. The patients were followed up for two years; the primary endpoint was recurrence and metastasis after surgery for colorectal cancer, and the secondary endpoint was death due to any cause. The Kaplan-Meier method was used to investigate the difference in cumulative survival rate after surgery for colorectal cancer. Results Compared with the control group, the treatment group had a higher 1-year cumulative disease-free survival rate （97.44% vs 94.87%, χ2=0.000, P=1.000）, a significant increase in 2-year cumulative disease-free survival rate （92.31% vs 71.79%, χ2 = 5.571, P=0.018）, and significant prolongation of progression-free survival （23.4±2.3 months vs 21.2±5.1 months, t=2.361, P=0.021）. Conclusion In patients receiving chemotherapy after surgery for colorectal cancer, Jiawei Xiangsha Liujunzi Decoction can effectively reduce recurrence and metastasis rates and improve postoperative survival time.

关 键 词：大肠癌 香砂六君子汤 生存分析 

分 类 号：R735.3[医药卫生—肿瘤] R273[医药卫生—临床医学]