Wnt信号通路介导胆固醇逆向转运与炎症应答的交互作用  

Crosstalk between reverse cholesterol transport and inflammatory response mediated by Wnt signaling pathway in atherosclerosis

作　　者：张婵娟 覃丽 ZHANG Chanjuan;QIN Li(Department of Pharmacology,School of Pharmacy,Hunan University of Chinese Medicine,Changsha,Hunan 410208,China)

机构地区：[1]湖南中医药大学药学院药理学教研室

出　　处：《中国动脉硬化杂志》2018年第8期843-850,共8页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(81774130);湖南省自然科学基金杰出青年基金项目(2018JJ1018);湖南省教育厅重点项目(15A138)

摘　　要：动脉粥样硬化是以脂质代谢紊乱、内皮损伤、单核-巨噬细胞浸润及血栓形成为主要病理特征的慢性炎症性疾病。近年来证实Wnt信号通路在动脉粥样硬化斑块的启动和进展中发挥重要作用。Wnt家族是富含半胱氨酸的分泌型糖蛋白,其通过经典和非经典通路参与多种生物学过程的调控。研究发现Wnt家族及其信号通路是协调胆固醇逆向转运（RCT）和炎症应答之间交互作用的关键平台,也是促进动脉粥样硬化病变的重要参与者。本文就Wnt家族及其信号通路与RCT和炎症应答之间的交互作用作一综述,以期为动脉粥样硬化的预防和治疗提供科学的理论依据。Atherosclerosis（ As） is a chronic inflammatory disease characterized by dyslipidemia,monocyte-macrophage infiltration,endothelial injury,and thrombosis. Recently,Wnt family plays an important role in the initiation and progression of atherosclerotic plaque. Wnt family is a cysteine-rich secreted glycoprotein which involved in the regulation of various biological processes through both canonical and non-canonical pathways. Previous studies suggest that Wnt family and its signaling pathways regulate the interaction between reverse cholesterol transport（ RCT） and inflammatory responses,and play an important role in triggering atherosclerotic lesions. This review summarized the mechanisms of RCT and inflammatory response via Wnt family and its signaling pathway,which might provide novel diagnostic and therapeutic strategies for prevention and treatment of As.

关 键 词：WNT信号通路 胆固醇逆向转运 炎症应答 交互作用 动脉粥样硬化 

分 类 号：R363[医药卫生—病理学]