孤儿核受体Nr6a1的生物学功能与表达调控机制  

Biological Function and Expression Regulation Mechanism of Orphan Nuclear Receptor Nr6a1

作　　者：刘晓雯[1] 刘华伟 王伟龙 李丹[1] LIU Xiaowen;LIU Huawei;WANG Weilong;LI Dan(College of Biology,Hunan University,Changsha 410082,Hunan,China)

机构地区：[1]湖南大学生物学院,湖南长沙410082

出　　处：《激光生物学报》2018年第3期199-204,217,共7页Acta Laser Biology Sinica

基　　金：国家自然科学基金资助项目(81571494)

摘　　要：孤儿核受体亚家族6成员1(nuclear receptor subfamily 6 group member1,Nr6a1)是激活配体转录因子的核受体超家族成员,也称为生殖细胞核因子(germ cell nuclear factor,GCNF)或视黄酸受体相关睾丸相关核受体(retinoic acid receptor-related testis-associated receptor,RTR)。作为转录因子,Nr6a1通过与靶基因启动子区的DR0元件(TCAAGGTCA)结合发挥转录抑制作用。Nr6a1主要高表达于成熟的生殖细胞、分化阶段的胚胎干细胞以及畸胎瘤等生殖细胞肿瘤中,具有一定的时空表达特异性和组织表达特异性。目前已鉴定了一批Nr6a1的上、下游调控分子,包括miR-181a、let7、Oct4、PPARδ等,通过基因间的互作,Nr6a1在细胞分化、发育、代谢等生物学过程中发挥重要调节作用。Nuclear receptor subfanfily 6 group menlberl （ Nr6al ） is an active ligand transcription factor menlber of the nuclear receptor supeffanfily, also known as germ cell nuclear factor （GCNF） or retinoie acid receptor-related testis-as- sociated receptor （RTR）. As a transcription factor, Nr6al play-s a role of transcriptional inhibition by binding to the DR0 element （TCAAGGTCA） in the target gene promoter region. Nr6al is mainly expressed in mature germ cells, dif- ferentiated embryonic stem cells and germ cell tumors such as teratoma, which suggested that the expression profile of Nr6al is spatio-temporal specificity and tissue specificity. To date, a number of upstream or downstream of Nr6al regulato- ry molecules including miR-181a, let7, Oct4, PPARδ have been identified. Through the interactions with these genes, Nr6al play-s an important regulating role in biological processes of development, cell differentiation and metabolism.

关 键 词：Nr6a1 DR0元件 转录抑制 分化 发育 

分 类 号：R730.2[医药卫生—肿瘤] Q78[医药卫生—临床医学]