爪哇毛霉脂肪酶催化合成2-氨基噻吩衍生物  

Synthesis of 2-Aminothiophene Derivatives Catalyzed by Amano Lipase M from Mucor javanicus

作　　者：卢粤 姜国芳[1] 谢宗波[1] 陈国庆 乐长高[1] Lu Yue;Jiang Guofang;Xie Zongbo;Chen Guoqing;Le Zhanggao(Department of Applied Chemistry,East China University of Technology,Nanchang 330013)

机构地区：[1]东华理工大学应用化学系,南昌330013

出　　处：《有机化学》2018年第7期1837-1841,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21462001;21262002;21465002);江西省科技计划(No.20161BCB24006);江西省教育厅科技(Nos.KJLD14050;GJJ150584)资助项目~~

摘　　要：以α-活性亚甲基腈和2,5-二羟基-1,4-二噻烷为原料,通过爪哇毛霉脂肪酶催化的Gewald反应合成了一系列2-氨基噻吩类化合物.该方法与传统的化学催化方法相比,具有反应条件温和、催化剂可生物降解、底物适用范围较宽泛等优点.A series of 2-aminothiophene derivatives were synthesized by the Gewald reaction between α-active methylene nitrilthes and 2,5-dihydroxy-1,4-dithiane using amano lipase M from Mucorjavanicus as biocatalyst. The method has the advantages of mild reaction conditions, biodegradability of catalyst and wide range of substrates compared with traditional catalysts.

关 键 词：α-活性亚甲基腈 2 5-二羟基-1 4-二噻烷 脂肪酶 Gewald反应 2-氨基噻吩 

分 类 号：O626.12[理学—有机化学]