磁弛豫开关传感器在医学诊断及食品安全检测中的研究进展  

Progresses of Magnetic Relaxation Switch Sensor in Medical Diagnosis and Food Safety Analysis

作　　者：谷桂英 王欣[1] 周化岚 刘宝林[1] GU Gui-Ying;WANG Xin;ZHOU Hua-Lan;LIU Bao-Lin(School of Medical Instrument and Food Engineering,University of Shanghai for Science and Technology,Shanghai 200093,Chin)

机构地区：[1]上海理工大学医疗器械与食品学院,上海200093

出　　处：《分析化学》2018年第8期1161-1170,共10页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金项目(Nos.81773482;31201365);上海市科委重点攻关项目(No.11142200403)资助~~

摘　　要：临床生化或食品复杂体系样本的快速、准确检测对于保障人类健康有重要意义。基于磁性纳米粒子的磁弛豫开关传感器是集纳米、核磁共振、化学、生物免疫分析技术于一体的的新型传感器,具有快速、无损、灵敏、特异性强、可检测浑浊溶液样品等优点。本文在简述超顺磁弛豫开关传感器检测原理的基础上,对MRS的检测目标物、传感器构造特点、检测灵敏度及检测过程中T_2的变化规律进行了归纳总结,对其应用于检测多种医学诊断生物标志物和食品中重要有害因子的研究进行了评述,并从磁纳米粒子的制备与修饰、磁弛豫开关传感器检测灵敏度的提高及高通量磁弛豫传感器的构建等方面提出了解决策略。Fast and accurate detection of complex samples in either medical diagnosis or food safety analysis is of great significance for the safeguarding of human health. The magnetic relaxation switches（ MRS） technology based on superparamagnetic nanoparticles（ SMP） is the combination of nano-biotechnology,nuclear magnetic resonance,chemistry and immunoassay. MRS assay has the characteristics of high sensitivity and specificity,as well as nondestructive and time-saving,and can be used in turbid complex samples. In this paper,with brief discussion about the detection theory of superparamagnetic nanosensor, the target type, structural characteristics,limit of detection,state of magnetic nanoparticles and the change of T2 value of MRS were reviewed. The research progresses of magnetic relaxation switch sensor in medical diagnosis of different biomarkers and the analysis of food hazard factor were also summarized. Accordingly,the future research targets from three aspects,e. g.,preparation and modification of magnetic nanoparticles,the improvement of detection sensitivity and construction of high flux magnetic relaxation switch sensor,have been put forward.

关 键 词：超顺磁纳米粒子 磁弛豫开关传感器 医学诊断 食品安全 检测 评述 

分 类 号：R446[医药卫生—诊断学] TP212[医药卫生—临床医学] TS201.6[自动化与计算机技术—检测技术与自动化装置]