丁苯酞辅助治疗急性脑梗死对颈动脉斑块大小及神经功能的影响  

Effect of Butylphthalide on carotid plaque size and neurological function in patients with acute ischemic stroke

作　　者：邱宇 彭湘杭 张永顺 曾淑云 温倩茹 QIU Yu;PENG Xiang-hang;ZHANG Yong-shun(Department of Neurology,Dongguan Changping Hospital,Dongguan 523560,Chin)

机构地区：[1]东莞市常平医院神经内科,523560 [2]东莞市常平医院内分泌科,523560 [3]东莞市常平医院肾内科,523560

出　　处：《中国现代药物应用》2018年第14期1-3,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨丁苯酞辅助治疗急性脑梗死对颈动脉斑块大小及神经功能的影响。方法 102例急性脑梗死患者,采用数字随机分组法分为治疗组与对照组,各51例。两组患者均采用基础治疗,对照组患者采用依达拉奉注射液治疗,治疗组在对照组基础上加用丁苯酞软胶囊治疗。比较两组患者的颈动脉斑块、运动功能及神经功能情况。结果治疗前,两组患者美国国立卫生研究院卒中量表(NIHSS)评分比较,差异无统计学意义(P>0.05);治疗后,两组患者NIHSS评分均低于治疗前,且治疗组的(6.9±1.7)分低于对照组的(8.3±2.5)分,差异有统计学意义(P<0.05);治疗前,两组患者上下肢Fugl-Meyer(FMA)评分比较,差异无统计学意义(P>0.05);治疗后,两组患者上下肢FMA评分均明显高于治疗前,且治疗组高于对照组,差异有统计学意义(P<0.05);治疗前,两组患者斑块大小及颈动脉内中膜厚度比较,差异无统计学意义(P>0.05);治疗后,两组斑块大小及颈动脉内中膜厚度均小于治疗前,且治疗组小于对照组,差异有统计学意义(P<0.05)。结论丁苯酞有改善颈动脉内中膜厚度、斑块大小,恢复神经功能的效果。Objective To investigate the effect of Butylphthalide on carotid plaque size and neurological function in patients with acute ischemic stroke. Methods 102 patients with acute ischemic stroke admitted to our hospital were divided into the treatment group and the control group according to the random number table method, 51 cases in each group. Petients of two groups were given basic treatment. The control group was treated with Edaravone Injection, while the treatment group was treated with Butylphthalide Soft Capsules on the basis of control group. The carotid plaque size, motor function and neurological function between two groups were compared. Results There was no statistically significant difference in the National Institutes of Health Stroke Scale（NIHSS） between the two groups before treatment（P〈0.05）. After treatment, the NIHSS scores of two groups were significantly lower than before treatment, and the NIHSS score of treatment group was（6.9±1.7） scores, which was significantly lower than（8.3±2.5） scores of control group, the differences were statistically significant（P〈0.05）. There was no statistically significant difference in the Fugl-Meyer（FMA） score of upper and lower extremities between the two groups before treatment（P〈0.05）. After treatment, the FMA score of upper and lower extremities in the two groups were significantly higher than before treatment, and that of treatment group was significantly higher than control group, the differences were statistically significant（P〈0.05）. There were no statistically significant differences in the carotid plaque size and carotid intima-media thickness between the two groups before treatment（P〉0.05）. After treatment, the carotid plaque size and carotid intima-media thickness of two groups were significantly smaller than before treatment, those of treatment group were significantly smaller than the control group, the differences were statistically significant（P〉0.05）. Conclusion Butylphthalide can improve caro

关 键 词：丁苯酞 急性脑梗死 劲动脉斑块大小 神经功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]