基于常规X线的光栅成像改善微钙化X线摄影的对比度  

Improved contrast of microcalcification on radiographs using grating-based X-ray imaging

作　　者：王升平 李新斌[2] 朱晓骅 付怡 李瑞敏 张丽[2] 陈志强[2] 彭卫军 WANG Shengping;LI Xinbin;ZHU Xiaohua;FU Yi;LI Ruimin;ZHANG Li;CHEN Zhiqiang;PENG Weijun(Department of Diagnostic Radiology,Fudan University Shanghai Cancer Center Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China;Department of Engineering Physics,Tsinghua University,Key Laboratory of Particle and Radiation Imaging,Ministry of Education,Beijing 100084,China)

机构地区：[1]复旦大学附属肿瘤医院放射诊断科,复旦大学上海医学院肿瘤学系,上海200032 [2]清华大学工程物理系,教育部粒子与辐射成像重点实验室,北京100084

出　　处：《肿瘤影像学》2018年第3期157-163,共7页Oncoradiology

摘　　要：目的:通过微钙化模型光栅成像,探讨不同组织厚度和微钙化大小条件下光栅成像微钙化的显示情况。方法:选择磷酸钙模拟乳腺微钙化,新鲜瘦猪肉模拟乳腺组织,制作乳腺微钙化模型。分别对3组不同猪肉厚度(2、4和5 cm)和5组不同颗粒大小(16、22、26、30和40目)的微钙化模型(每组10粒钙化)成像。比较不同猪肉厚度和钙化大小条件下吸收成像与暗场成像对比度的差异。结果:在所有不同厚度模型组,暗场成像对比度均优于吸收成像,两种成像方式之间差异有统计学意义(P<0.000 1)。随着猪肉厚度增加,吸收成像对比度明显下降,暗场成像对比度轻度下降。在所有不同钙化大小模型组,暗场成像对比度也均优于吸收成像,两种成像方式之间差异有统计学意义(P<0.000 1)。随着钙化减小,吸收成像对比度明显降低,暗场成像对比度略有降低。结论:基于光栅的暗场成像可提高微钙化的对比度,改善微钙化的可视化,有望提高微钙化的检出率。光栅成像在乳腺癌微钙化的检出和诊断中有广阔的应用前景。Objective： To investigate the visualization of microcalcification in microcalcification models with different tissue thicknesses and microcalcification sizes by using grating-based X-ray imaging. Methods： Tricalcium phosphate was used to simulate breast microcalcification and fresh lean pork was used to simulate breast tissues. Grating-based X-ray imaging was performed in the pork with different thickness（2, 4 and 5 cm） and different particle sizes（16 mesh, 22 mesh, 26 mesh, 30 mesh and 40 mesh）. The contrast of absorption imaging and dark field imaging under different conditions was compared. Results： The contrast of dark-field imaging was better than that of absorption imaging in the models with different thicknesses（P〈0.000 1）. The contrast of absorption imaging decreased significantly while that of dark-field imaging decreased slightly with increasing pork thickness. The contrast of darkfield imaging was also better than that of absorption imaging in the models with different micro calcification sizes（P〈0.000 1）. The contrast of absorption imaging decreased significantly while that of dark-field imaging decreased slightly with decreasing micro calcification size. Conclusion： Dark-field imaging could improve the contrast and visualization of microcalcifications, and has the potential to improve the detection rate of microcalcifications. Gratingbased imaging has a broad application prospect in the detection and diagnosis of microcalcification in breast cancer.

关 键 词：光栅成像 X线 乳腺 微钙化 模型研究 

分 类 号：R730.44[医药卫生—肿瘤] R737.9[医药卫生—临床医学]