异种脱细胞真皮基质预防Frey综合征的临床作用分析  

Analysis of Clinical Role of Xenogeneic Acellular Dermal Matrix in Prevention of Frey Syndrome

作　　者：张文静 左金华[1] ZHANG Wen-jing;ZUO Jin-hua(Binzhou Medical College,Binzhou 256600,Chin)

机构地区：[1]滨州医学院,山东滨州256600

出　　处：《中国医药指南》2018年第12期25-26,共2页Guide of China Medicine

摘　　要：目的分析异种脱细胞真皮基质在预防腮腺良性肿瘤术后Frey综合征中的作用。方法选择2016年1月至2017年12月诊断腮腺良性肿瘤患者200例,依据术中手术方式不同,分为4组,各50例。所有患者均给予腮腺肿瘤与浅叶组织切除。A组(对照组),不保留患侧咬肌筋膜。B组,保留咬肌筋膜组;C组,异种脱细胞真皮基质组。D组,保留咬肌筋膜与异种脱细胞真皮基质联合使用组。随访6个月,比较4组患者术后发生Frey综合征比率,分析各组患者手术时间、术中出血、手术费用、术后涎瘘、面神经麻痹、肿瘤复发比率。结果咬肌筋膜保留组、异种脱细胞真皮基质组与联合组患者术后Frey综合征发生率差异无统计学意义(P>0.05),但与对照组比较显著降低,差异均有统计学意义(P<0.05)。对照组、咬肌筋膜保留组、异种脱细胞真皮基质组与联合组患者术中出血量、术后涎瘘、面神经麻痹、肿瘤复发比例差异无统计学意义(P>0.05)。咬肌筋膜保留组、异种脱细胞真皮基质组与联合组患者手术时间高于对照组,组间比较差异有统计学意义(P<0.05)。异种脱细胞真皮基质组与联合组手术费用明显高于其余2组患者,差异有统计学意义(P<0.05)。结论腮腺咬肌筋膜保留、异体脱细胞真皮基质应用在术后防治Frey综合征临床疗效相当,但异体脱细胞真皮基质手术费用显较高。异体脱细胞真皮基质与咬肌筋膜保留组联合应用对于防治Frey综合征发生无显著意义,但手术费用明显增加。Objective To analyze the role of xenoacellular dermal matrix in the prevention of Frey syndrome. Methods From January 2016 to December 2017, 200 patients with parotid benign tumors were divided into four groups according to different operative methods. All patients were treated with parotid tumor and superfcial lobe tissue resection. The A group, as the name of the control group （50 cases）, did not retain the lateral masseter fascia. In group B （50 cases）, the masseter fascia was retained during the resection of tumor tissue. Group C, there were 50 cases of xenogeneic acellular dermal matrix. No masseter fascia was reserved during operation. Group D, group of the masseter fascia retained and xenoacellular dermal matrix （50 cases）. After six months follow-up, the incidence of postoperative Frey syndrome was compared among the four groups. The operative time, intraoperative bleeding, operative cost, postoperative salivary fstula, facial nerve paralysis and tumor recurrence rate were analyzed. Venous blood was taken in the morning fasting after one weeks, two weeks, March and June respectively. Results There was no signifcant difference in the incidence of Frey syndrome between the masseter muscle fascia preservation group, the xenogeneic acellular dermal matrix group and the combined group after operation（P〉0.05）. But compared with the control group, the difference was statistically signifcant（P〈0.05）.In control group, masseter muscle fascia preservation group, xenogeneic acellular dermal matrix group and combined group, there was no signifcant difference in bleeding volume, postoperative salivary fstula, facial nerve paralysis and tumor recurrence rate （P〉0.05）. The operation time of masseter muscle fascia preservation group, xenogeneic acellular dermal matrix group and combined group were higher than those of the control group. The difference between the two groups was statistically signifcant （P〈0.05）. The operation cost of the xenoacellular dermal matrix group and the combi

关 键 词：腮腺肿瘤 并发症 咬肌筋膜 异体脱细胞真皮基质 味觉出汗综合征 

分 类 号：R739.87[医药卫生—肿瘤]