子宫内膜样腺癌中结肠癌转移相关因子和血管内皮生长因子的表达及其与患者预后的关系  被引量:2

Expression of MACC1 and VEGF in endometrial adenocarcinoma and correlation of patient prognosis with it

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作  者:梁晓霞[1] 高宝红[1] 刘改萍[1] Liang Xiaoxia;Gao Baohong;Liu Gaiping(Department of Pathology,Shanxi Traditional Chinese Medical Hospital,Taiyuan 030012,China)

机构地区:[1]山西省中医院病理科,太原030012

出  处:《山西医药杂志》2018年第13期1530-1533,共4页Shanxi Medical Journal

摘  要:目的检测结肠癌转移相关因子(MACC1)和血管内皮生长因子(VEGF)在子宫内膜样腺癌中的表达,探讨两者之间的关系及与子宫内膜样腺癌的临床病理特征及患者预后的关系。方法采用免疫组织化学法对68例子宫内膜样腺癌组织和30例正常的子宫内膜组织中MACC1和VEGF的表达,并运用χ2检验分析比较各临床病理特征与MACC1、VEGF表达的相关性。二者表达的相关性分析采用Spearman法分析。分别采用Kaplan-Meier法和Log-rank法绘制生存曲线图以及MACC1、VEGF表达与患者预后关系。结果 (1)MACC1和VEGF在子宫内膜样腺癌中的阳性表达率高于正常的子宫内膜(P<0.05);(2)MACC1和VEGF在临床Ⅲ期中的表达率显著高于临床Ⅰ~Ⅱ期,伴淋巴结转移组MACC1、VEGF表达率高于不伴淋巴结转移组,浸润肌层>1/2组MACC1表达率高于≤1/2组(P<0.05)。(3)MACC1和VEGF在子宫内膜样腺癌中的表达呈正相关(r=0.572,P=0.000)。(4)MACC1蛋白阳性组的子宫内膜样腺癌患者生存时间与阴性组相比显著缩短(P=0.028)。VEGF蛋白的表达与患者总生存时间无关。结论 MACC1和VEGF可能参与了子宫内膜样腺癌的发生、发展,并且与其高侵袭性和转移相关,二者可能是相互协同的作用,MACC1高表达提示预后不良。Objective To detect the expression of MACC1 and VEGF proteins in endometrioid adenocarcinoma and to explore the correlation between the expression and the clinicpathologica1 features of endometrioid adenocarcinoma and prognosis of the patients.Methods Immunehistochemical evaluation was performed to detect the expression of VEGF and MACC1 proteins in 68 cases of adenocarcinoma tissue and 30 cases of normal endometrium. chi-square test analysis was used to compare the correlation of clinical pathologic characteristics and MACC1,VEGF expression. The correlation analysis of the two protein expressions was analyzed by Spearman method. According to the data of the follow-up, Kaplan-Meier method and log-rank method were used to draw the survival curve and the correlation between MACC1,VEGF levels and the prognosis of patients. Results ①The positive rates of MACC1 and VEGF in endometrioid adenocarcinoma were higher than those in the normal endometrial group ( P 〈0.05). ②The positive rate of MACC1 and VEGF in stage Ⅲ was significantly higher than that in stage Ⅰ-Ⅱ and was higher in those with lymph node metastasis than those without lymph node metastasis; The expression rate of MACC1 is higher in those with infiltrating muscular layer 〉 1/2 than those in ≤1/2 ( P 〈0.05). ③the expression of MACC1 and VEGF in endometrioid adenocarcinoma was positively correlated ( r=0.572, P=0.000). ④In MACC1 positive group, the survival time of patients was significantly shorter than that in the negative group ( P =0.028). The expression of VEGF was independent of the patient's total survival time.Conclusion MACC1 and VEGF are involved in the occurrence and development of endometrioid adenocarcinoma, indicating high invasion and metastasis. The two proteins are synergistic and the higher expression of MACC1 indicates poor prognosis.

关 键 词:直肠肿瘤 手助腹腔镜检查 肿瘤标记 生物学 

分 类 号:R737.33[医药卫生—肿瘤]

 

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