宫颈癌介入化疗后患者EGFR蛋白表达变化及疗效分析  

Changes of EGFR protein expression and clinical efficacy in patients with cervical cancer after interventional chemotherapy

作　　者：杜宇 杨卫东 崔铱婕 许敏 陈洪波 李磊 贾江涛 张欣 张祎 DU Yu, YANG Weidong, CUI Yijie, et al(The Second Hospital of Baoding City, Hebei, Baoding 071051, Chin)

机构地区：[1]河北省保定市第二医院,071051

出　　处：《河北医药》2018年第16期2445-2448,共4页Hebei Medical Journal

摘　　要：目的探讨宫颈癌介入化疗后患者表皮生长因子受体(EGFR)蛋白表达变化情况及临床疗效。方法选取2012年12月至2016年1月收治的94例宫颈癌患者(观察组)和同期60例宫颈正常的患者(对照组)作为研究对象。采用回顾性分析法分析所有患者的临床资料,根据其临床资料可知所有宫颈癌患者均行介入化疗治疗和EGFR蛋白的检测,详细记录宫颈癌组织和正常宫颈组织以及介入化疗前后患者间EGFR蛋白的表达情况和宫颈癌患者介入化疗后的临床效果,并比较上述不同患者间EGFR蛋白及其他相关临床资料的差异性,分析影响宫颈癌介入化疗临床效果的相关因素。结果宫颈癌患者其癌组织中EFGR蛋白阳性表达率显著高于正常宫颈组织中,而宫颈癌患者经介入化疗治疗后其EFGR蛋白的阳性表达率显著下降,差异有统计学意义(P<0.05);本组94例宫颈癌患者均行介入化疗治疗,其临床总有效率为87.23%(82/94);不同组织分化程度、不同EFGR蛋白表达以及是否淋巴结转移的宫颈癌患者经介入化疗后其临床有效率比较差异均有统计学意义(P<0.005);经非条件多因素Logistic回归模型分析可得,低分化、EFGR阳性率过高以及出现淋巴结转移均为应县宫颈癌介入化疗临床有效率的独立危险因素(P<0.05)。结论介入化疗可显著降低宫颈癌患者其EFGR蛋白其阳性表达率,且EFGR蛋白阳性过高表达以及低分化和出现淋巴结转移均为影响宫颈癌介入化疗后临床有效率的独立危险因素。Objective To investigate the changes of expression of epidermal growth factor receptor（ EGFR） protein in patients with cervical cancer after interventional chemotherapy and its clinical efficacy. Methods A total of 94 patients with cervical cancer who were admitted and treated in our hospital from December 2012 to January 2016 were enrolled as observation group,at the sema time,the other 60 patients with normal cervix were enrolled as control group. The clinical data of all the patients were retrospectively analyzed,according to the clinical data,all the patients with cervical cancer underwent interventional chemotherapy and EGFR protein detection. The EGFR protein expression before and after interventional chemotherapy and clinical curative effects were observed,moreover, the influencing factors on the rapeutic effects of interventional chemotherapy were analyzed. Results The positive expression rate of EFGR protein in cervical cancer tissues was significantly higher than that in normal cervical tissues,and the positive expression rate of EFGR protein in cervical cancer patients after interventional chemotherapy was significantly decreased,there was significant difference between two groups（ P 0. 05）. The clinical effective rate in observation group was 87. 23%（ 82/94）. There were significant differences in clinical effective rates among different degree of tissue differentiations,different expression levels of EFGR protein and lymph node metastasis in patients with cervical cancer after interventional chemotherapy（ P 0. 05）. The multivariate Logistic regression analysis showed that low differentiation,low differentiation,higher EFGR positive expression rate and lymph node metastasis were the independent risk factors of the clinical effective rate of interventional chemotherapy（ P 0. 05）. Conclusion The interventional chemotherapy can significantly reduce the positive expression rate of EFGR protein in patients with cervical cancer,and the overexpression of EFGR protein,low differentiation an

关 键 词：宫颈癌 介入化疗 表皮生长因子受体蛋白 表达情况 临床疗效 

分 类 号：R737.33[医药卫生—肿瘤]