高效液相色谱-串联质谱法测定食品接触材料及制品中27种全氟化合物迁移量  

Determination of the Migration of 27 Perfluorinated Compounds in Food Contact Materials by High Performance Liquid Chromatography-Tandem Mass Spectrometry

作　　者：王晶[1,2] 张子豪 麦晓霞[1] 肖前[1] 翟翠萍[1] 刘莹峰[1] 郑建国[1] 李攻科[2] WANG Jing;ZHANG Zi-hao;MAI Xiao-xia;XIAO Qian;ZHAI Cui-ping;LIU Ying-feng;ZHENG Jian-guo;LI Gong-ke(Guangdong Entry -Exit Inspection and Quarantine Bureau,Guangzhou 510623,Chana;School of Chemistry and Chemical Engineering,Sun Yat-sen University,Guangzhou 510275,China)

机构地区：[1]广东出入境检验检疫局,广东广州510623 [2]中山大学化学与化学工程学院,广东广州510275

出　　处：《分析测试学报》2018年第5期570-575,共6页Journal of Instrumental Analysis

基　　金：国家重点研发计划(2016YFF0203705)

摘　　要：建立了食品接触材料迁移模拟环境中27种全氟化合物的高效液相色谱-串联质谱检测方法。选取乙酸(3%)、乙醇(10%、50%)和橄榄油作为食品模拟物,模拟了食品接触材料在与不同类型食物接触下的迁移行为,根据(EU)No.10/2011的要求对样品进行处理,每6 dm2食品接触材料加入1 L食品模拟物浸泡。水相模拟物经过滤后直接检测,橄榄油经乙腈提取后进行检测。模拟溶液样品以甲醇-水混合溶液为流动相,经C18色谱柱分离,在MRM模式下进行检测。结果表明:全氟化合物在1~1 000μg/L质量浓度范围内线性关系良好(r>0.999 1);全氟化合物在食物模拟物中的定量下限为0.28~9.85μg/kg;对空白样品进行10、100 ng两个浓度水平的加标回收试验,加标回收率为82.6%~112.1%,相对标准偏差为2.2%~7.2%。A high performance liquid chromatography-tandem mass spectrometric（HPLC-MS/MS）method was developed for the determination of the migration of 27 perfluorinated compounds in food contact materials using 3% acetic acid,10% alcohol,50% alcohol and olive oil as food simulants.Samples were soaked in 1 L different kinds of food simulants every 6 dm^2 food contact materials according to（EU） No. 10/2011. The water-based simulant samples could be analyzed directly after filteration,and the olive oil stimulant samples should be extracted with acetonitrile before analysis. The simulated solution samples were separated on a C18 column with methanol-water as mobile phase,and analyzed under multiple reaction monitoring（MRM） mode. The results showed that there existed good linearities（r 0. 999 1） for 27 perfluorinated compounds in the range of 1-1 000 μg/L. The LOQs of PCFs were in the range of 0. 28-9. 85 μg/kg in food simulants. The recoveries for 27 perfluorinated compounds in blank samples at two spiked levels of 10 and 100 ng ranged from 82. 6% to112. 1% with relative standard deviations（RSDs） of 2. 2%-7. 5%.

关 键 词：食品接触材料 全氟化合物 高效液相色谱-串联质谱 迁移量 

分 类 号：O657.63[理学—分析化学] TL281[理学—化学]