脑微透析技术在神经精神疾病中的研究进展  

Research progress and application prospect of bain microdialysis in neuropsychiatric diseases

作　　者：宋宇尘 韩新民[2] 袁海霞[2] 雷爽 SONG Yu-chen;HAN Xin-min;YUAN Hai-xia;LEI Shuang(Departrnertt of Pediatrics,Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,Jiangsu,China;First Clinical Medical College,Nanjing University of Chinese Medicine,Nanjing 210023,Jiangsu,China)

机构地区：[1]南京中医药大学附属医院儿科,南京医学硕士研究生210029 [2]南京中医药大学第一临床医学院,南京210023

出　　处：《医学研究生学报》2018年第7期750-755,共6页Journal of Medical Postgraduates

基　　金：国家自然科学基金(81503614;81273801)

摘　　要：脑微透析是一种可对采集样品进行连续、在线、实时定量分析的技术,近年来在脑内神经递质的检测中应用广泛,在神经精神疾病的研究中有广阔的发展前景,但因其操作复杂、价格昂贵、耗时长、个体差异大、探针重现性不良等而受到限制。进一步优化实验设计、发展多位点微透析是下一步的方向,神经精神疾病脑内微环境代谢状态变化的监测是微透析技术用于此的另一前景。文章就脑微透析技术的原理、特点及操作要点,神经递质与神经精神疾病之间的关系,以及脑微透析在神经精神疾病中的研究进展进行综述。Brain microdialysis（BMD） is a technique for continuous,on-line and real-time quantitative analysis for collected samples and it has been widely used in the quantitative detection of neurotransmitters in the brain in recent years. BMD has broad prospects in the research of neuropsychiatric diseases,but it is limited in studies because of its complicated operation,high cost,long time consuming,individual difference and poor reproducibility of the probe. Optimizing experimental design and developing multilocus microdialysis are main directions of research. Monitoring the changes of the metabolic state of the brain microenvironment in the neuropsychiatric diseases is another prospect of BMD. This article reviews the principle,characteristics and key points of brain microdialysis,along with the relationship between neurotransmitters and neuropsychiatric diseases,and the progress of microdialysis in neuropsychiatric diseases.

关 键 词：脑微透析 神经精神疾病 神经递质 

分 类 号：R74[医药卫生—神经病学与精神病学]