血清HE4、CA125、ROMA联合检测在上皮性卵巢癌诊断中的应用  

Application of serum HE4,CA125,ROMA combine detection in epithelial ovarian cancer diagnosis

作　　者：畅华[1] 张雪[1] 李白雪 姚霁航[1] 郭科军[1] Chang Hua;Zhang Xue;Li Baixue;Yao Jihang;Guo Kejun(Department of Gynecology,The First Affiliated Hospital of China Medical University,Liaoning Shenyang 110001,China)

机构地区：[1]中国医科大学附属第一医院妇科,辽宁沈阳110004

出　　处：《现代肿瘤医学》2018年第15期2434-2436,共3页Journal of Modern Oncology

摘　　要：目的:观察HE4、CA125、ROMA值及联合检测对早期卵巢癌风险的预测价值。方法:收集确诊为卵巢肿物女性患者术前的血清样本,分析血清HE4、CA125的表达水平和ROMA值,并与术后病理结果对比,使用受试者工作曲线(ROC-curve)做数据跟踪分析。结果:血清HE4、CA125表达水平和ROMA值在恶性组中高于其他组(P<0.001)。ROMA值良性组与健康组比较差异无显著性(P>0.05)。在早期卵巢癌血清肿瘤标志物对比中,HE4+CA125+ROMA的联合检测与其它血清标志物的差异有显著性(P<0.01),敏感度98.7%;特异度74.6%;准确度71.5%。结论:在早期卵巢癌检测中HE4单独检测有最高的灵敏度,但HE4+CA125+ROMA联合检测可以在早期更加准确的预测早期卵巢恶性肿瘤的风险。Objective：To observe the prognostic value of HE4，CA125，ROMA values and combined detection in the early ovarian cancer risk prediction.Methods：The serum samples from female patients who were diagnosed as ovarian tumor were collected before operation.The expression level of serum HE4，CA125 and ROMA value were analyzed，and compared with the post-operation pathological results.The data tracking analysis was done with the subject work curve （ROC-curve）.Results：The expression level of serum HE4，CA125 and the value of ROMA in the malignant group were higher than those in the other groups （P〈0.001）.The ROMA value was not significantly different between the benign group and the healthy group （P〉0.05）.In the comparison of serum tumor markers in early ovarian cancer，the differences between the combined detection of HE4＋CA125＋ROMA and the other serum markers was significant （P〈0.01），sensitivity was 98.7%，specificity was 74.6%，and accuracy was 71.5%.Conclusion：HE4 has the highest sensitivity in the early detection of ovarian cancer alone.However，the combined detection of HE4＋CA125＋ROMA can be more accurate in predicting the risk of early ovarian malignant tumors.

关 键 词：上皮性卵巢癌 人附睾蛋白4(HE4) 糖类抗原125(CA125) 卵巢癌风险指数(ROMA) 联合检测 

分 类 号：R737.31[医药卫生—肿瘤]