吸烟对酒精性脂肪肝的影响  

Analysis of the Effects of Smoking and Drinking on Alcoholic Fatty Liver Disease

作　　者：张进忠 张秀芝 李宁宁 雷延飞 刘晓丽[2] 亢春彦 陈洁 ZHANG Jin-zhong 1, ZHANG Xiu-zhi 1, LI Ning-ning 1, LEI Yan-fei 1,LIU Xiao-li 2, KANG Chun-yan 1, CHEN Jie 1(1.Henan Medical College, Zhengzhou Henan 451191, China;2.Henan Province People＇s Hospital, Zhengzhou Henan 450003, Chin)

机构地区：[1]河南医学高等专科学校,郑州451191 [2]河南省人民医院,郑州450003

出　　处：《河南医学高等专科学校学报》2018年第4期327-330,共4页Journal of Henan Medical College

基　　金：河南省科技攻关计划项目(142102310441)

摘　　要：目的了解吸烟在酒精性脂肪肝发生发展中的作用及戒烟戒酒对患者血清生化指标的影响。方法选择226例酒精性脂肪肝患者资料,分为吸烟组142例和非吸烟组84例,分别对其进行6个月的戒烟戒酒行为干预,比较干预前后两组饮酒习惯与血清生化指标情况。结果干预前吸烟组患者饮酒量(66.20±30.30)g/d和饮酒年限(5.40±3.60)a均少于非吸烟组(75.40±25.70)g/d、(6.80±3.90)a,差异均有统计学意义(P<0.05);血清总胆固醇(TC)、低密度脂蛋白(LDL)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)和γ-谷氨酰转移酶(γ-GGT)高于非吸烟组;高密度脂蛋白(HDL)低于非吸烟组,差异均有统计学意义(P<0.05);两组患者戒烟戒酒6个月后,TC、LDL、AST、ALT和γ-GGT均较之前降低,HDL升高,差异有统计学意义(P<0.05);吸烟组患者戒烟戒酒组与仅戒酒组相比,血清LDL、ALT和AST明显降低,HDL明显升高,差异均有统计学意义(P<0.05)。结论饮酒人群中,吸烟者相对非吸烟者发生酒精性脂肪肝的饮酒年限更短和饮酒量更少;相对非吸烟者,吸烟且饮酒对酒精性脂肪肝患者肝功能及血脂影响更明显;戒酒的同时戒烟可更加有效地降低TC和LDL,升高HDL,有效降低血清酶水平,戒烟是酒精性脂肪肝重要的治疗性干预措施。Objective To explore the effects of smoking on the development of alcoholic fatty liver disease and to analyse the effects of smoking cessation and abstinence on the serum biochemical indexes of the patients.Methods A total of 226 alcoholic fatty liver patients were divided into smoking group （142） and non-smoking group （84）. A intervention of smoking cessation and abstinence for 6 months were applied to the patients. The drinking history and the serum indexes of the smokers and the non-smokers were compared. Serum indexes of the patients before and after smoking cessation and alcohol withdrawal were analyzed for the two groups, respectively.Results The average drinking and drinking years（66.20± 30.30）g/d and （5.40±3.60）a, reapectively） in the smoking group were less than those（75.40± 25.70 ）g/d, （6.80±3.90）a, respectively in the non-smoking group （ P 〈0.05）. Total cholesterol （TC）, low density lipoprotein（LDL）, alanine aminotransferase （ALT）, aspartate aminotransferase（AST） and gamma glutamyl transferase （γ-GGT） were significantly higher in patients of alcoholic fatty liver disease with smoking habits than that of the patients with non-smoking habits （ P 〈0.05）. But for the high density lipoprotein（HDL）, it was significantly lower in the smoking group. After 6 months of smoking cessation and abstinence or abstinence only, the TC, LDL, AST, ALT and γ-GGT of the patients were significantly lower, while the HDL was significantly higher than before the intervention （ P 〈0.05）. Among the patients with smoking habits, compared with the patients quitting drinking only, the serum LDL, ALT and AST decreased significantly in the patients quitting smoking and quitting drinking （ P 〈0.05）, while the HDL increased. The differences were all statistically significant （ P 〈0.05）.Conclusion Among the drinkers, shorter alcohol consumption and less alcohol consumption are needed for smokers to have alcoholic fatty liver disease. The effects

关 键 词：酒精性脂肪肝 吸烟 酒精 血清酶 血脂 

分 类 号：R575.5[医药卫生—消化系统]