GTF2H1基因rs3802967多态性与肺癌易感性的关联性  

Association between the polymorphism of rs3802967 in GTF2H1 gene and susceptibility of lung cancer

作　　者：钱成 包阳 徐月娟[3] 李玉涛 王一 张艳红 郭士成 赵振宏[4] 李强 卢大儒[4,8] 金力 王久存[4,8] 吴俊杰 QIAN Cheng;BAO Yang;XU Yue-juan;LI Yu-tao;WANG Yi;ZHANG Yan-hong;GUO Shi-cheng;ZHAO Zhen-hong;LI Qiang;LU Da-ru;JIN Li;WANG Jiu tun;WU Jun jie(Department of Throcic Surgery,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Department of Cardiothoracic Surgery,the Affiliated Hospital of Yangzhou University,Yangzhou 225000,Jiangsu Province,China;Department of Oncology,the Second Hospital of Nanjing,Nanjing 210003,Jiangsu Province,China;State Key Laboratory of Genetic Engineering,School of Life Sciences,5 School Infirmary,Fudan University,Shanghai 200433,China;6 Center for Human Genetics,Marsh field Clinic Research Institute,Marsh field 54449,WI,USA;7Department of Respiratory and Critical Care Medicine,Changhai Hospital,Naval Medical University,Shanghai 200433,Chin;8 Fudan-Taizhou Institute of Health Sciences,Taizhou 225300,Jiangsu Province,Chin)

机构地区：[1]复旦大学附属中山医院胸外科,上海200032 [2]扬州大学附属医院心胸外科,扬州225000 [3]南京市第二医院肿瘤内科,南京210003 [4]复旦大学生命科学学院遗传工程国家重点实验室,上海200433 [5]复旦大学校医院,上海200433 [6]美国威斯康星州马什菲尔德临床研究所人类遗传中心,马什菲尔德54449 [7]海军军医大学附属长海医院呼吸与危重症医学科,上海200433 [8]复旦大学泰州健康科学研究院,泰州225300

出　　处：《复旦学报（医学版）》2018年第4期454-461,共8页Fudan University Journal of Medical Sciences

摘　　要：目的探索GTF2 H1基因rs3802967位点多态性与肺癌相关性。方法采集肺癌及健康受试者外周血进行基因分型,非条件Logistic回归分析该位点多态性与肺癌易感性之间相关性。结果共收集上海及泰州地区885例肺癌患者和896例健康受试者外周血进行基因分型分析,结果显示rs3802967 CT+TTvs.CC总体上肺癌风险显著增加(OR=1.943,95%CI:1.559~2.426,P=3.989×10-9),吸烟患者(CT+TTvs.CC,OR=2.382,95%CI:1.798~3.167,P=1.813×10-9)、男性患者(CT+TT vs.CC,OR=2.141,95%CI:1.644~2.796,P=1.852×10-8)以及男性吸烟患者(CT+TTvs.CC,OR=2.283,95%CI:1.709~3.059,P=2.718×10-8)肺癌风险显著增加。结论 GTF2 H1基因rs3802967 C>T与肺癌患病风险正相关,尤其在男性、吸烟患者中显著,该位点有望成为肺癌易感个体筛查参考指标。Objective To investigate the association of GTF2H1 rs3802967 polymorphism with lung cancer. Methods Lung cancer cases and healthy controls were recruited, genotyping, unconditional logistic regression to assess the susceptibility to lung cancer. Results A total of 885 lung cancer cases and 896 healthy controls were recruited,rs3802967 significantly increased the risk of lung cancer （CT＋TTvs. CC,OR 1. 943,95%CI：1. 559 2.426,P 3.989×10 9）.Insmokers （CT＋TTvs. CC,OR 2.382,95%CI：1. 798 3. 167,P 1. 813 × 10 9）,male groups （CT＋ TT vs. CC, OR 2.141,95%CI：1. 644 2.796,P 1.852×10 8） ,and nlale smokers （CT＋ TT vs. CC,OR 2.283,CT ＋TTvs. CC,95%CI：l.709 3.059,P 2. 718×10 8）,rs3802967 significantly increased the risk of lung cancer. Conclusions GTF2H1 rs3802967 C〉T is significantly associated with the risk of lung cancer,especially among male, smokers,which suggests that this SNP can be a marker for lung cancer susceptibility screening.

关 键 词：GTF2H1基因 rs3802967 多态性 肺癌 病例-对照研究 

分 类 号：R734.2[医药卫生—肿瘤] Q311[医药卫生—临床医学]