运动训练诱发脑缺血耐受的机制研究进展  

The research progress in the mechanism of brain ischemic tolerance induced by exercise training

作　　者：张峰[1,2] 董芳 董国栋[4] 秦晓军[1] Zhang Feng;Dong Fang;Dong Guodong;Qin Xiaojun(Department of Rehabilitation Medicine;Department of Clinical Laboratory Medicine;Hebei Provincial Orthopedic Biomechanics Key Laboratory,The Third Hospital of Hebei Medical University,Shijiazhuang 050051,China;No.93523 PLA Army Station Hospital,Yongji,044500,China)

机构地区：[1]河北医科大学第三医院康复科 [2]河北医科大学第三医院河北省骨科生物力学重点实验室 [3]河北医科大学第三医院检验科 [4]中国人民解放军93523部队场站医院

出　　处：《中华老年骨科与康复电子杂志》2018年第4期247-251,共5页Chinese Journal of Geriatric Orthopaedics and Rehabilitation(Electronic Edition)

基　　金：国家自然科学基金资助(81201512)

摘　　要：运动训练能够减轻脑缺血发生后的运动功能障碍,临床和基础研究均对其作用机制进行了深入探索。但是,关于缺血前的运动训练减轻脑缺血发生后神经损伤的具体机制尚不明确,本文就其相关机制进行了综述。缺血前运动训练可通过降低炎症反应,减少神经细胞凋亡,减轻血脑屏障功能障碍,改善脑血管系统,减轻谷氨酸毒性,从而诱发脑缺血耐受。运动训练的神经保护作用机制的阐明有利于针对脑卒中高危人群进行运动干预,减轻缺血性脑卒中后神经功能障碍,产生良好的社会效益。Exercise training could alleviate the motor dysfunction following cerebral ischemia.Clinical and basic experimental study studies have explored the mechanism underlying this phenomenon.However, the exact mechanism of pre-ischemic exercise intervention on nerve damage after cerebral ischemia is still not clear, which was summarized in this review. Exercise preconditioning could reduce inflammation reaction, decrease neuron apoptosis, alleviate blood brain barrier dysfunction, improve cerebrovascular system and mitigate glutamate toxicity, thus inducing brain ischemic tolerance. The elucidation of neuroprotective effect of exercise training is helpful for implementation of exercise intervention for stroke high risk population, reducing neurological deficits following ischemic stroke,resulting in beneficial influence on the whole society.

关 键 词：康复 脑缺血 运动训练 

分 类 号：R743.3[医药卫生—神经病学与精神病学]