前列腺癌病灶内垂体肿瘤转化基因1与增殖、侵袭基因的相关性研究  

The correlation of pituitary tumor transforming gene1 with proliferation and invasion genes in prostate cancer

作　　者：余洋[1] 熊飞[1] 董自强[1] 陈晓波[1] 董传江[1] 张路生[1] YU Yang;XIONG Fei;DONG Zi-qiang;CHEN Xiao-bo;DONG Chuan-jiang;ZHANG Lu-sheng(Department of Urology Surgery,the First Clinical Medical College of China Three Gorges University,Yichang Central People＇s Hospital,Yichang,Hubei Province,443000,Chin)

机构地区：[1]三峡大学第一临床医学院宜昌市中心人民医院泌尿外科,湖北宜昌443000

出　　处：《海南医学院学报》2018年第10期1030-1033,共4页Journal of Hainan Medical University

基　　金：国家自然科学青年科学基金(81300626)~~

摘　　要：目的:研究前列腺癌病灶内垂体肿瘤转化基因1(PTTG1)表达量的变化及其与增殖、侵袭基因的相关性。方法:选择在我院接受根治性手术的前列腺癌患者作为研究的恶性组并收集前列腺癌病灶,另取同期因良性前列腺增生在我院接受前列腺电切治疗的患者作为研究的良性组并收集前列腺良性病灶,测定病灶内PTTG1、增殖基因、侵袭基因的mRNA表达量。结果:恶性组患者前列腺癌病灶内PTTG1、Survivin、Bcl-2、CyclinD1、GPRC6A、ZEB1、CatB、CatD、PAR-1的mRNA表达量显著高于良性组,CDKN2、p21、TFPI2的mRNA表达量显著低于良性组;高PTTG1的前列腺癌病灶内Survivin、Bcl-2、CyclinD1、GPRC6A、ZEB1、CatB、CatD、PAR-1的mRNA表达量显著高于低PTTG1的前列腺癌病灶,CDKN2、p21、TFPI2的mRNA表达量显著低于低PTTG1的前列腺癌病灶。结论:前列腺癌病灶内PTTG1基因呈高表达且与增殖、侵袭基因表达的变化密切相关。Objective： To study the change of pituitary tumor transforming gene 1 （PTTG1） expression in prostate cancer and its correlation with proliferation and invasion genes. Methods： Patients with prostate cancer who underwent radical operation in our hospital between March 2015 and January 2018 were selected as the malignant group of the research, and the prostate cancer lesions were collected; patients who underwent transurethral resection of the prostate due to benign prostatic hyperplasia in our hospital during the same period were selected as the benign group of the research, and the benign prostate lesions were collected. The mRNA expression levels of PTTG1, proliferation genes and invasion genes in the lesions were determined. Results： PTTG1, Survivin, Bcl-2, CyclinD1, GPRC6A, ZEB1, CatB, CatD and PAR-1 mRNA expression in prostate cancer lesions of malignant group were significantly higher than those of benign group whereas CDKN2, p21 and TFPI2 mRNA expression were significantly lower than those of benign group （ P 〈0.05）; Survivin, Bcl-2, CyclinD1, GPRC6A, ZEB1, CatB, CatD and PAR-1 mRNA expression in prostate cancer lesions with high PTTG1 were significantly higher than those in prostate cancer lesions with low PTTG1 whereas CDKN2, p21 and TFPI2 mRNA expression were significantly lower than those in prostate cancer lesions with low PTTG1（ P 〈0.05）. Conclusion： The PTTG1 gene is highly expressed in prostate cancer lesions and it is closely related to the changes of proliferation and invasion gene expression.

关 键 词：前列腺癌 垂体肿瘤转化基因1 增殖 侵袭 

分 类 号：R737.25[医药卫生—肿瘤]