基质金属蛋白酶-7启动子(-181A/G)基因多态性与消化道肿瘤易感性的Meta分析  

Association between promoter polymorphisms of matrix metalloproteinases-7(-181A/G) and risk of digestive cancers: A Meta-analysis

作　　者：陈欢 张祎[1] 蔡小旭 潘志红[1] Chen Huan;Zhang Yi;Cai Xiaoxu;Pan Zhihong(Department of Gastroenterology,People＇s Hospital of Three Gorges University ＆ The First People＇s Hospital of Yichang,Hubei Yichang 443000,Chin)

机构地区：[1]三峡大学人民医院&宜昌市第一人民医院消化内科,湖北宜昌443000

出　　处：《现代肿瘤医学》2018年第16期2578-2584,共7页Journal of Modern Oncology

摘　　要：目的:评价基质金属蛋白酶-7(MMP-7)启动子(-181A/G)基因多态性与消化道肿瘤易感性的关系。方法:计算机检索各大医学数据库,对2017年7月前公开发表的关于MMP-7(-181A/G)基因多态性的病例对照研究进行Meta分析。结果:共19项研究符合纳入标准,累计病例数3 296例,对照组4 362例。从总体效应量分析,除隐性基因模型外,MMP-7(-181A/G)基因多态性与消化道肿瘤易感性有关,差异有统计学意义(G vs A,OR=1.25,95%CI:1.09~1.43,P=0.00;GG/AG vs AA,OR=1.25,95%CI:1.12~1.39,P=0.00;GG vs AA,OR=1.42,95%CI:1.03~1.94,P=0.03;AG vs AA,OR=1.21,95%CI:1.07~1.35,P=0.00)。进一步分层分析表明MMP-7(-181A/G)基因多态性与胃癌、食管鳞癌的易感性有关,但并不能确定是否增加结直肠癌的发生风险。按照种族进行亚组分析,提示MMP-7(-181A/G)基因多态性能够显著增加亚洲人群的消化道肿瘤的发生率。结论:MMP-7(-181A/G)基因多态性与消化道肿瘤有关,G等位基因增加了食管鳞癌、胃癌的发生风险。Objective：To explore the association between of MMP-7 gene polymorphism and digestive cancer susceptibility.Methods：Data bases were comprehensively searched to retrieve all related data,Meta-analysis of case-control studies on the association between MMP-7 gene polymorphism and digestive cancer in published up to July 2017.Results：19 original studies fulfilled the inclusion criteria with a total of 3 296 patients and 4 362 controls entered into study dataset.Meta-analysis showed that the significant association between MMP-7（-181A/G）polymorphism and digestive cancer was found under the allele model（G vs A,OR=1.25,95%CI：1.09~1.43,P=0.00）,dominant model（GG/AG vs AA,OR=1.25,95%CI：1.12~1.39,P=0.00）,homozygous model（GG vs AA,OR=1.42,95%CI：1.03~1.94,P=0.03）,heterozygous model（AG vs AA,OR=1.21,95%CI：1.07~1.35,P=0.00） except for recessive model（GG vs AG/AA,OR=1.30,95%CI：0.96~1.76）.Further stratification analysis showed that MMP-7（-181A/G） polymorphism was associated with susceptibility to gastric cancer and esophageal cancer,but it was not possible to determine the risk of colorectal cancer.Subgroup analysis by ethnicity suggested that MMP-7（-181A/G） gene polymorphisms can significantly increase the incidence of digestive cancers in the Asian population.Conclusion：This Meta-analysis demonstrated that MMP-7（-181A/G） polymorphism was associated with digestive cancers,and the G allele may increases the risk of esophageal and gastric cancer.

关 键 词：MMP-7 基因多态性 消化道肿瘤 META分析 

分 类 号：R735[医药卫生—肿瘤]